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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Maternal embryonic leucine zipper kinase | ||
| Ligand | BDBM177573 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Kinase Assay | ||
| pH | 7.4±n/a | ||
| Temperature | 298.15±n/a K | ||
| IC50 | 1.2±n/a nM | ||
| Comments | extracted | ||
| Citation |  Matsuo, Y; Hisada, S; Nakamura, Y; Ahmed, F; Huntley, R; Walker, JR; Decornez, H Quinoline derivatives and MELK inhibitors containing the same US Patent US9120749 Publication Date 9/1/2015 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Maternal embryonic leucine zipper kinase | |||
| Name: | Maternal embryonic leucine zipper kinase | ||
| Synonyms: | KIAA0175 | MELK | MELK_HUMAN | Maternal embryonic leucine zipper kinase | Maternal embryonic leucine zipper kinase (MELK) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 74665.45 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q14680 | ||
| Residue: | 651 | ||
| Sequence: |
| ||
| BDBM177573 | |||
| n/a | |||
| Name | BDBM177573 | ||
| Synonyms: | US9120749, 940 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H26ClN3O3 | ||
| Mol. Mass. | 439.935 | ||
| SMILES | COc1cc(cc(Cl)c1O)-c1ccc2ncc(C(C)=O)c(N[C@H]3CC[C@H](N)CC3)c2c1 |r,wU:25.26,wD:22.22,(-7.53,-1.41,;-6.2,-2.18,;-4.87,-1.41,;-3.53,-2.18,;-2.2,-1.41,;-2.2,.13,;-3.53,.9,;-3.53,2.44,;-4.87,.13,;-6.2,.9,;-.86,-2.18,;-.86,-3.72,;.47,-4.49,;1.8,-3.72,;3.14,-4.49,;4.47,-3.72,;4.47,-2.18,;5.8,-1.41,;7.14,-2.18,;5.8,.13,;3.14,-1.41,;3.14,.13,;2.05,1.22,;2.45,2.71,;1.36,3.8,;-.13,3.4,;-1.22,4.49,;-.53,1.91,;.56,.82,;1.8,-2.18,;.47,-1.41,)| | ||
| Structure | 
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