| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM178030 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | DHFR Inhibition Assay |
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| pH | 7.5±n/a |
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| IC50 | 5.9e+2±n/a nM |
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| Comments | extracted |
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| Citation |  Tian, C; Zhang, Z; Zhou, S; Yuan, M; Wang, X; Liu, J Synthesis, Antifolate and Anticancer Activities of N(5) -Substituted 8,10-Dideazatetrahydrofolate Analogues. Chem Biol Drug Des87:444-54 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 21453.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant human DHFR. |
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| Residue: | 187 |
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| Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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| BDBM178030 |
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| n/a |
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| Name | BDBM178030 |
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| Synonyms: | N-[4-[2-(2,4-Diamino-5-formyl-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl)methyl]amino]benzoyl]-L-glutamic acid (24a) |
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| Type | Small organic molecule |
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| Emp. Form. | C21H25N7O6 |
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| Mol. Mass. | 471.4665 |
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| SMILES | Nc1nc(N)c2N(C=O)C(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)CCc2n1 |r| |
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| Structure | 
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