| Reaction Details |
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 | Report a problem with these data |
| Target | Apoptosis regulator Bcl-2 |
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| Ligand | BDBM178562 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) Assay |
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| Ki | 0.001±n/a nM |
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| Citation |  Bruncko M; Ding H; Doherty GA; Elmore SW; Hasvold L; Hexamer LA; Kunzer AR; Mantei RA; McClellan WJ; Park CH; Park C; Petros AM; Song X; Souers AJ; Sullivan GM; Tao Z; Wang GT; Wang L; Wang X; Wendt MD Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases US Patent US9125913 Publication Date 9/8/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| Apoptosis regulator Bcl-2 |
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| Name: | Apoptosis regulator Bcl-2 |
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| Synonyms: | n/a |
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| Type: | Protein |
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| Mol. Mass.: | 26409.44 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | P10417 |
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| Residue: | 236 |
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| Sequence: | MAQAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDADAAPLGAAPTPGIFSFQPESNPMPA
VHRDMAARTSPLRPLVATAGPALSPVPPVVHLTLRRAGDDFSRRYRRDFAEMSSQLHLTP
FTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNR
HLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
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| BDBM178562 |
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| n/a |
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| Name | BDBM178562 |
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| Synonyms: | US9125913, 121 |
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| Type | Small organic molecule |
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| Emp. Form. | C47H54ClN7O7S |
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| Mol. Mass. | 896.492 |
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| SMILES | CN(C)CCOc1ccc(c(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(NCCCN4CCCC4)c(c3)[N+]([O-])=O)c(Oc3ccccc3)c2)c1)-c1ccc(Cl)cc1 |
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| Structure | 
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