Reaction Details |
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Target | Apoptosis regulator Bcl-2 |
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Ligand | BDBM178854 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) Assay |
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Ki | 0.007±n/a nM |
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Citation | Bruncko, M; Ding, H; Doherty, GA; Elmore, SW; Hasvold, L; Hexamer, LA; Kunzer, AR; Mantei, RA; McClellan, WJ; Park, CH; Park, C; Petros, AM; Song, X; Souers, AJ; Sullivan, GM; Tao, Z; Wang, GT; Wang, L; Wang, X; Wendt, MD Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases US Patent US9125913 Publication Date 9/8/2015 |
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More Info.: | Get all data from this article, Assay Method |
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Apoptosis regulator Bcl-2 |
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Name: | Apoptosis regulator Bcl-2 |
Synonyms: | BCL2_MOUSE | Bcl-2 | Bcl2 |
Type: | Protein |
Mol. Mass.: | 26409.44 |
Organism: | Mus musculus (Mouse) |
Description: | P10417 |
Residue: | 236 |
Sequence: | MAQAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDADAAPLGAAPTPGIFSFQPESNPMPA
VHRDMAARTSPLRPLVATAGPALSPVPPVVHLTLRRAGDDFSRRYRRDFAEMSSQLHLTP
FTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNR
HLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
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BDBM178854 |
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n/a |
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Name | BDBM178854 |
Synonyms: | US9125913, 426 |
Type | Small organic molecule |
Emp. Form. | C47H54Cl2N8O7S |
Mol. Mass. | 945.952 |
SMILES | CN(C)CC(=O)N1CCO[C@@H](COc2ncc(cc2Cl)S(=O)(=O)NC(=O)c2ccc(cc2Oc2cccc3[nH]ncc23)N2CCN(CC3=C(CC(C)(C)CC3)c3ccc(Cl)cc3)CC2)C1 |t:51| |
Structure |
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