Reaction Details |
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Target | Hematopoietic prostaglandin D synthase |
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Ligand | BDBM179447 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Fluorescence Polarization Binding Assay (FPBA) |
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Temperature | 298.15±n/a K |
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IC50 | 4000±n/a nM |
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Comments | extracted |
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Citation | Endres, GW; Lee, PH; Olson, KL; Kramer, JB; Ciske, FL; Barrett, SD Multiheteroaryl compounds as inhibitors of H-PGDS and their use for treating prostaglandin D2 mediated diseases US Patent US9126973 Publication Date 9/8/2015 |
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More Info.: | Get all data from this article, Assay Method |
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Hematopoietic prostaglandin D synthase |
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Name: | Hematopoietic prostaglandin D synthase |
Synonyms: | GSTS | Glutathione-dependent PGD synthetase | Glutathione-requiring prostaglandin D synthase | H-PGDS | HPGDS | HPGDS_HUMAN | Hematopoietic prostaglandin D synthase | Hematopoietic prostaglandin D synthase (H-PGDS) | Hematopoietic prostaglandin D synthase (HPGDS) | PGDS | PTGDS2 | Prostaglandin D | Prostaglandin D Synthase |
Type: | Enzyme |
Mol. Mass.: | 23341.07 |
Organism: | Homo sapiens (Human) |
Description: | The protein was expressed in E. coli strain BL21(DE3) with an N-terminal 6-His tag. |
Residue: | 199 |
Sequence: | MPNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPEIKSTLPFGKIPILEVDGLT
LHQSLAIARYLTKNTDLAGNTEMEQCHVDAIVDTLDDFMSCFPWAEKKQDVKEQMFNELL
TYNAPHLMQDLDTYLGGREWLIGNSVTWADFYWEICSTTLLVFKPDLLDNHPRLVTLRKK
VQAIPAVANWIKRRPQTKL
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BDBM179447 |
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n/a |
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Name | BDBM179447 |
Synonyms: | US9126973, 38 |
Type | Small organic molecule |
Emp. Form. | C19H14N4O |
Mol. Mass. | 314.3407 |
SMILES | O(c1ccccc1)c1ncc(cn1)-c1cnc([nH]1)-c1ccccc1 |
Structure |
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