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TargetCholesteryl ester transfer protein
LigandBDBM179502
Substrate/Competitorn/a
Meas. Tech.Scintillation Proximity Assay (SPA)
pH7.4±n/a
Temperature298.15±n/a K
IC50 428±n/a nM
Commentsextracted
Citation Anand, RColandrea, VJReiter, MVachal, PZwicker, AWilson, JEZhang, FZhao, K Substituted benzopiperazines as CETP inhibitors US Patent US9126976 Publication Date 9/8/2015
More Info.:Get all data from this article,  Assay Method
 
Cholesteryl ester transfer protein
Name:Cholesteryl ester transfer protein
Synonyms:CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I
Type:Enzyme
Mol. Mass.:54751.53
Organism:Homo sapiens (Human)
Description:P11597
Residue:493
Sequence:
MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDI
TGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTT
AWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWI
KQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVI
TASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRL
MLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSS
VMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSE
SVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGF
PEHLLVDFLQSLS
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  Blast E-value cutoff:
BDBM179502
n/a
NameBDBM179502
Synonyms:US9126976, 33
TypeSmall organic molecule
Emp. Form.C26H24F6N2O
Mol. Mass.494.472
SMILESCc1ccccc1CN1C[C@H](N(C[C@@H](O)C(F)(F)F)c2ccccc12)c1cccc(c1)C(F)(F)F |r|
Structure
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