Compile Data Set for Download or QSAR

Found 2660 hits with Last Name = 'wilson' and Initial = 'je'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphodiesterase (Macaca mulatta (Rhesus macaque))	BDBM331979 ((R)- or (S)-2- (3,4-dimethoxy- benzyl)-6-(1-(1- (2...) Show SMILES COc1ccc(Cc2nc(cc(=O)[nH]2)-c2cn(cn2)C(C)c2ccc(cc2F)C(F)(F)F)cc1OC Show InChI	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...				US Patent US10195201 (2019) BindingDB Entry DOI: 10.7270/Q20G3N7K
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM385987 ((R)- or (S)-5- (hydroxymethyl)-2- methyl-7-(1-(4-(...) Show SMILES CC(c1nc(CO)c2n1nc(C)[nH]c2=O)c1ccc(cc1)C1(C)CC1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin at Madison					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				J Med Chem 51: 7243-52 (2008) BindingDB Entry DOI: 10.7270/Q2G1634M
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM331979 ((R)- or (S)-2- (3,4-dimethoxy- benzyl)-6-(1-(1- (2...) Show SMILES COc1ccc(Cc2nc(cc(=O)[nH]2)-c2cn(cn2)C(C)c2ccc(cc2F)C(F)(F)F)cc1OC Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description TBD				US Patent US10195201 (2019) BindingDB Entry DOI: 10.7270/Q20G3N7K
					More data for this Ligand-Target Pair
Phosphodiesterase (Macaca mulatta (Rhesus macaque))	BDBM331979 ((R)- or (S)-2- (3,4-dimethoxy- benzyl)-6-(1-(1- (2...) Show SMILES COc1ccc(Cc2nc(cc(=O)[nH]2)-c2cn(cn2)C(C)c2ccc(cc2F)C(F)(F)F)cc1OC Show InChI	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...				US Patent US10195201 (2019) BindingDB Entry DOI: 10.7270/Q20G3N7K
					More data for this Ligand-Target Pair
Phosphodiesterase (Macaca mulatta (Rhesus macaque))	BDBM355246 (US9815796, Example 337) Show SMILES CC(C)(C)[C@@H](NC(=O)c1cc(=O)[nH]c(n1)-c1ccccc1)c1ccc(cc1)C(F)(F)F |r| Show InChI	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD R & D (China) Co. LTD. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US9815796 (2017) BindingDB Entry DOI: 10.7270/Q2V69MQQ
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM408573 (US10358435, Example 89 | US10358435, Example 90) Show SMILES COc1ccc(Cc2nc(cc(=O)[nH]2)-c2nnn3c2CCC[C@@]3(C)c2ccc(cc2F)C(F)(F)F)cc1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US10358435 (2019) BindingDB Entry DOI: 10.7270/Q2Q242M7
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM408558 (US10358435, Example 74 | US10358435, Example 75) Show SMILES C[C@H](c1cn(nn1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1Cl)C(F)(F)F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.420	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US10358435 (2019) BindingDB Entry DOI: 10.7270/Q2Q242M7
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM354912 (1-Methylcyclopropanamine Oxalate | US9815796, Exam...) Show SMILES COc1ccc(Cc2nc(cc(=O)[nH]2)C(=O)NC2(CC2)c2ccc(cc2)C(F)(F)F)cc1OC Show InChI InChI=1S/C24H22F3N3O4/c1-33-18-8-3-14(11-19(18)34-2)12-20-28-17(13-21(31)29-20)22(32)30-23(9-10-23)15-4-6-16(7-5-15)24(25,26)27/h3-8,11,13H,9-10,12H2,1-2H3,(H,30,32)(H,28,29,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.450	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD R & D (China) Co. LTD. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US9815796 (2017) BindingDB Entry DOI: 10.7270/Q2V69MQQ
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM355376 (N-{(1R)-2,2-dimethyl-1-[4- (trifluoromethoxy)pheny...) Show SMILES COc1ccc(Cc2nc(cc(=O)[nH]2)C(=O)N[C@@H](c2ccc(OC(F)(F)F)cc2)C(C)(C)C)cc1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.490	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD R & D (China) Co. LTD. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US9815796 (2017) BindingDB Entry DOI: 10.7270/Q2V69MQQ
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM355552 (N-{(1S)-1-[2-chloro-4- (trifluoromethyl)phenyl]-2-...) Show SMILES C[C@](CO)(NC(=O)c1cc(=O)[nH]c(n1)-c1ccccc1)c1ccc(cc1Cl)C(F)(F)F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD R & D (China) Co. LTD. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US9815796 (2017) BindingDB Entry DOI: 10.7270/Q2V69MQQ
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM355445 (N-[(1R)-1-(4-cyclopropylphenyl)- 2,2-dimethylpropy...) Show SMILES CC(C)(C)[C@@H](NC(=O)c1cc(=O)[nH]c(n1)-c1ccccc1)c1ccc(cc1)C1CC1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.510	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD R & D (China) Co. LTD. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US9815796 (2017) BindingDB Entry DOI: 10.7270/Q2V69MQQ
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM354913 (2-Methyl-2-(1H-pyrazol-1-yl)propanimidamide acetat...) Show SMILES COc1ccc(Cc2nc(cc(=O)[nH]2)C(=O)N[C@H](C)c2ccc(cc2)C(F)(F)F)cc1OC |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.520	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD R & D (China) Co. LTD. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US9815796 (2017) BindingDB Entry DOI: 10.7270/Q2V69MQQ
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM408512 (US10358435, Example 29) Show SMILES CC(N=[N+]=[N-])c1ccc(cc1Cl)C(F)(F)F Show InChI InChI=1S/C9H7ClF3N3/c1-5(15-16-14)7-3-2-6(4-8(7)10)9(11,12)13/h2-5H,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.530	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US10358435 (2019) BindingDB Entry DOI: 10.7270/Q2Q242M7
					More data for this Ligand-Target Pair
Phosphodiesterase (Macaca mulatta (Rhesus macaque))	BDBM354912 (1-Methylcyclopropanamine Oxalate | US9815796, Exam...) Show SMILES COc1ccc(Cc2nc(cc(=O)[nH]2)C(=O)NC2(CC2)c2ccc(cc2)C(F)(F)F)cc1OC Show InChI InChI=1S/C24H22F3N3O4/c1-33-18-8-3-14(11-19(18)34-2)12-20-28-17(13-21(31)29-20)22(32)30-23(9-10-23)15-4-6-16(7-5-15)24(25,26)27/h3-8,11,13H,9-10,12H2,1-2H3,(H,30,32)(H,28,29,31)	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.540	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD R & D (China) Co. LTD. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US9815796 (2017) BindingDB Entry DOI: 10.7270/Q2V69MQQ
					More data for this Ligand-Target Pair
Phosphodiesterase (Macaca mulatta (Rhesus macaque))	BDBM354913 (2-Methyl-2-(1H-pyrazol-1-yl)propanimidamide acetat...) Show SMILES COc1ccc(Cc2nc(cc(=O)[nH]2)C(=O)N[C@H](C)c2ccc(cc2)C(F)(F)F)cc1OC |r| Show InChI	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.560	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD R & D (China) Co. LTD. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US9815796 (2017) BindingDB Entry DOI: 10.7270/Q2V69MQQ
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM408575 ((S)- or (R)-6-(7-(2-Fluoro-4- (trifluoromethyl)phe...) Show SMILES COc1cccc(Cc2nc(cc(=O)[nH]2)-c2nnn3c2CCCC3(C)c2ccc(cc2F)C(F)(F)F)c1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.560	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US10358435 (2019) BindingDB Entry DOI: 10.7270/Q2Q242M7
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM355364 (N-{(1R)-2,2-dimethyl-1-[4- (trifluoromethyl)phenyl...) Show SMILES COc1ccc(Cc2nc(cc(=O)[nH]2)C(=O)N[C@@H](c2ccc(cc2)C(F)(F)F)C(C)(C)C)cc1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD R & D (China) Co. LTD. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US9815796 (2017) BindingDB Entry DOI: 10.7270/Q2V69MQQ
					More data for this Ligand-Target Pair
Phosphodiesterase (Macaca mulatta (Rhesus macaque))	BDBM355373 (N-{(1R)-1-[3-fluoro-4- (trifluoromethoxy)phenyl]-2...) Show SMILES COc1ccc(Cc2nc(cc(=O)[nH]2)C(=O)N[C@@H](c2ccc(OC(F)(F)F)c(F)c2)C(C)(C)C)cc1 |r| Show InChI	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD R & D (China) Co. LTD. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US9815796 (2017) BindingDB Entry DOI: 10.7270/Q2V69MQQ
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM355374 (N-[(1R)-2,2-dimethyl-1-{4- [(trifluoromethyl)sulfa...) Show SMILES COc1ccc(Cc2nc(cc(=O)[nH]2)C(=O)N[C@@H](c2ccc(SC(F)(F)F)cc2)C(C)(C)C)cc1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.620	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD R & D (China) Co. LTD. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US9815796 (2017) BindingDB Entry DOI: 10.7270/Q2V69MQQ
					More data for this Ligand-Target Pair
Phosphodiesterase (Macaca mulatta (Rhesus macaque))	BDBM355376 (N-{(1R)-2,2-dimethyl-1-[4- (trifluoromethoxy)pheny...) Show SMILES COc1ccc(Cc2nc(cc(=O)[nH]2)C(=O)N[C@@H](c2ccc(OC(F)(F)F)cc2)C(C)(C)C)cc1 |r| Show InChI	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.620	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD R & D (China) Co. LTD. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US9815796 (2017) BindingDB Entry DOI: 10.7270/Q2V69MQQ
					More data for this Ligand-Target Pair
Phosphodiesterase (Macaca mulatta (Rhesus macaque))	BDBM355374 (N-[(1R)-2,2-dimethyl-1-{4- [(trifluoromethyl)sulfa...) Show SMILES COc1ccc(Cc2nc(cc(=O)[nH]2)C(=O)N[C@@H](c2ccc(SC(F)(F)F)cc2)C(C)(C)C)cc1 |r| Show InChI	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.620	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD R & D (China) Co. LTD. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US9815796 (2017) BindingDB Entry DOI: 10.7270/Q2V69MQQ
					More data for this Ligand-Target Pair
Phosphodiesterase (Macaca mulatta (Rhesus macaque))	BDBM408512 (US10358435, Example 29) Show SMILES CC(N=[N+]=[N-])c1ccc(cc1Cl)C(F)(F)F Show InChI InChI=1S/C9H7ClF3N3/c1-5(15-16-14)7-3-2-6(4-8(7)10)9(11,12)13/h2-5H,1H3	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.630	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US10358435 (2019) BindingDB Entry DOI: 10.7270/Q2Q242M7
					More data for this Ligand-Target Pair
Phosphodiesterase (Macaca mulatta (Rhesus macaque))	BDBM408573 (US10358435, Example 89 | US10358435, Example 90) Show SMILES COc1ccc(Cc2nc(cc(=O)[nH]2)-c2nnn3c2CCC[C@@]3(C)c2ccc(cc2F)C(F)(F)F)cc1 |r| Show InChI	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.630	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US10358435 (2019) BindingDB Entry DOI: 10.7270/Q2Q242M7
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM355366 (N-{(1R)-2,2-dimethyl-1-[4- (trifluoromethyl)phenyl...) Show SMILES COc1ccc(Cc2nc(cc(=O)[nH]2)C(=O)N[C@@H](c2ccc(cc2)C(F)(F)F)C(C)(C)C)cc1F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.640	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD R & D (China) Co. LTD. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US9815796 (2017) BindingDB Entry DOI: 10.7270/Q2V69MQQ
					More data for this Ligand-Target Pair
Phosphodiesterase (Macaca mulatta (Rhesus macaque))	BDBM355171 (2-cyclopropyl-N-{(1R)-2,2-dimethyl- 1-[4-(trifluor...) Show SMILES CC(C)(C)[C@@H](NC(=O)c1cc(=O)[nH]c(n1)C1CC1)c1ccc(cc1)C(F)(F)F |r| Show InChI	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.650	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD R & D (China) Co. LTD. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US9815796 (2017) BindingDB Entry DOI: 10.7270/Q2V69MQQ
					More data for this Ligand-Target Pair
Phosphodiesterase (Macaca mulatta (Rhesus macaque))	BDBM355364 (N-{(1R)-2,2-dimethyl-1-[4- (trifluoromethyl)phenyl...) Show SMILES COc1ccc(Cc2nc(cc(=O)[nH]2)C(=O)N[C@@H](c2ccc(cc2)C(F)(F)F)C(C)(C)C)cc1 |r| Show InChI	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.680	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD R & D (China) Co. LTD. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US9815796 (2017) BindingDB Entry DOI: 10.7270/Q2V69MQQ
					More data for this Ligand-Target Pair
Phosphodiesterase (Macaca mulatta (Rhesus macaque))	BDBM355366 (N-{(1R)-2,2-dimethyl-1-[4- (trifluoromethyl)phenyl...) Show SMILES COc1ccc(Cc2nc(cc(=O)[nH]2)C(=O)N[C@@H](c2ccc(cc2)C(F)(F)F)C(C)(C)C)cc1F |r| Show InChI	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.680	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD R & D (China) Co. LTD. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US9815796 (2017) BindingDB Entry DOI: 10.7270/Q2V69MQQ
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM355373 (N-{(1R)-1-[3-fluoro-4- (trifluoromethoxy)phenyl]-2...) Show SMILES COc1ccc(Cc2nc(cc(=O)[nH]2)C(=O)N[C@@H](c2ccc(OC(F)(F)F)c(F)c2)C(C)(C)C)cc1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.690	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD R & D (China) Co. LTD. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US9815796 (2017) BindingDB Entry DOI: 10.7270/Q2V69MQQ
					More data for this Ligand-Target Pair
Phosphodiesterase (Macaca mulatta (Rhesus macaque))	BDBM355417 (2-(3-fluoro-4-methoxybenzyl)-N- {(1R)-1-[3-fluoro-...) Show SMILES COc1ccc(Cc2nc(cc(=O)[nH]2)C(=O)N[C@@H](c2ccc(c(F)c2)C(F)(F)F)C(C)(C)C)cc1F |r| Show InChI	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.770	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD R & D (China) Co. LTD. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US9815796 (2017) BindingDB Entry DOI: 10.7270/Q2V69MQQ
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM355344 (2-cyclopropyl-N-[(1R)-1-(4- cyclopropyl-3-fluoroph...) Show SMILES CC(C)(C)[C@@H](NC(=O)c1cc(=O)[nH]c(n1)C1CC1)c1ccc(C2CC2)c(F)c1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.780	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD R & D (China) Co. LTD. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US9815796 (2017) BindingDB Entry DOI: 10.7270/Q2V69MQQ
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM355375 (N-{(1R)-1-[3-fluoro-4- (trifluoromethyl)phenyl]-2,...) Show SMILES COc1ccc(Cc2nc(cc(=O)[nH]2)C(=O)N[C@@H](c2ccc(c(F)c2)C(F)(F)F)C(C)(C)C)cc1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.790	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD R & D (China) Co. LTD. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US9815796 (2017) BindingDB Entry DOI: 10.7270/Q2V69MQQ
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM355171 (2-cyclopropyl-N-{(1R)-2,2-dimethyl- 1-[4-(trifluor...) Show SMILES CC(C)(C)[C@@H](NC(=O)c1cc(=O)[nH]c(n1)C1CC1)c1ccc(cc1)C(F)(F)F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.790	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD R & D (China) Co. LTD. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US9815796 (2017) BindingDB Entry DOI: 10.7270/Q2V69MQQ
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM355415 (2-(3-fluoro-4-methoxybenzyl)-N- {(1R)-1-[3-fluoro-...) Show SMILES COc1ccc(Cc2nc(cc(=O)[nH]2)C(=O)N[C@@H](c2ccc(OC(F)(F)F)c(F)c2)C(C)(C)C)cc1F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.800	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD R & D (China) Co. LTD. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US9815796 (2017) BindingDB Entry DOI: 10.7270/Q2V69MQQ
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM385981 ((R)- or (S)-7-(1-(2- fluoro-4- (trifluoromethyl) p...) Show SMILES CC(c1nc(CO)c2n1nc(C)[nH]c2=O)c1ccc(cc1F)C(F)(F)F Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.800	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin at Madison					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				J Med Chem 51: 7243-52 (2008) BindingDB Entry DOI: 10.7270/Q2G1634M
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM355417 (2-(3-fluoro-4-methoxybenzyl)-N- {(1R)-1-[3-fluoro-...) Show SMILES COc1ccc(Cc2nc(cc(=O)[nH]2)C(=O)N[C@@H](c2ccc(c(F)c2)C(F)(F)F)C(C)(C)C)cc1F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.800	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD R & D (China) Co. LTD. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US9815796 (2017) BindingDB Entry DOI: 10.7270/Q2V69MQQ
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM355372 (2-cyclopropyl-N-{(1R)-2,2- dimethyl-1-[4- (trifluo...) Show SMILES CC(C)(C)[C@@H](NC(=O)c1cc(=O)[nH]c(n1)C1CC1)c1ccc(OC(F)(F)F)cc1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.840	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD R & D (China) Co. LTD. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US9815796 (2017) BindingDB Entry DOI: 10.7270/Q2V69MQQ
					More data for this Ligand-Target Pair
Phosphodiesterase (Macaca mulatta (Rhesus macaque))	BDBM355171 (2-cyclopropyl-N-{(1R)-2,2-dimethyl- 1-[4-(trifluor...) Show SMILES CC(C)(C)[C@@H](NC(=O)c1cc(=O)[nH]c(n1)C1CC1)c1ccc(cc1)C(F)(F)F |r| Show InChI	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.850	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD R & D (China) Co. LTD. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US9815796 (2017) BindingDB Entry DOI: 10.7270/Q2V69MQQ
					More data for this Ligand-Target Pair
Phosphodiesterase (Macaca mulatta (Rhesus macaque))	BDBM355375 (N-{(1R)-1-[3-fluoro-4- (trifluoromethyl)phenyl]-2,...) Show SMILES COc1ccc(Cc2nc(cc(=O)[nH]2)C(=O)N[C@@H](c2ccc(c(F)c2)C(F)(F)F)C(C)(C)C)cc1 |r| Show InChI	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.850	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD R & D (China) Co. LTD. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US9815796 (2017) BindingDB Entry DOI: 10.7270/Q2V69MQQ
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM355382 (N-{(1R)-1-[3-fluoro-4- (trifluoromethoxy)phenyl]-2...) Show SMILES COc1ccc(Cc2nc(cc(=O)[nH]2)C(=O)N[C@H](C(C)C)c2ccc(OC(F)(F)F)c(F)c2)cc1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.860	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD R & D (China) Co. LTD. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US9815796 (2017) BindingDB Entry DOI: 10.7270/Q2V69MQQ
					More data for this Ligand-Target Pair
Phosphodiesterase (Macaca mulatta (Rhesus macaque))	BDBM355418 (N-{(1R)-2,2-dimethyl-1-[4- (trifluoromethoxy)pheny...) Show SMILES COc1ccc(Cc2nc(cc(=O)[nH]2)C(=O)N[C@@H](c2ccc(OC(F)(F)F)cc2)C(C)(C)C)cc1F |r| Show InChI	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.880	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD R & D (China) Co. LTD. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US9815796 (2017) BindingDB Entry DOI: 10.7270/Q2V69MQQ
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM385968 ((R)- or (S)-3- (1-(3- Fluoro- 4- (trifluoro- meth...) Show SMILES CC(c1nn(CCF)c2c1nc(C)[nH]c2=O)c1ccc(c(F)c1)C(F)(F)F Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.900	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin at Madison					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				J Med Chem 51: 7243-52 (2008) BindingDB Entry DOI: 10.7270/Q2G1634M
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM355378 (2-(4-methoxybenzyl)-N-[(1R)-2- methyl-1-{4- [(trif...) Show SMILES COc1ccc(Cc2nc(cc(=O)[nH]2)C(=O)N[C@H](C(C)C)c2ccc(SC(F)(F)F)cc2)cc1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.910	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD R & D (China) Co. LTD. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US9815796 (2017) BindingDB Entry DOI: 10.7270/Q2V69MQQ
					More data for this Ligand-Target Pair
Phosphodiesterase (Macaca mulatta (Rhesus macaque))	BDBM355415 (2-(3-fluoro-4-methoxybenzyl)-N- {(1R)-1-[3-fluoro-...) Show SMILES COc1ccc(Cc2nc(cc(=O)[nH]2)C(=O)N[C@@H](c2ccc(OC(F)(F)F)c(F)c2)C(C)(C)C)cc1F |r| Show InChI	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.920	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD R & D (China) Co. LTD. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US9815796 (2017) BindingDB Entry DOI: 10.7270/Q2V69MQQ
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50576278 (CHEMBL4863002) Show SMILES C[C@@H](c1nn(CCF)c2c1nc(C)[nH]c2=O)c1ccc(c(F)c1)C(F)(F)F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	0.920	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human PDE2				Citation and Details Article DOI: 10.1016/j.bmcl.2021.128082 BindingDB Entry DOI: 10.7270/Q2KK9GNG
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM408564 (US10358435, Example 80 | US10358435, Example 81) Show SMILES Cc1nc(cc(=O)[nH]1)-c1nnc2n1CCC[C@@]2(C)c1ccc(cc1F)C(F)(F)F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.930	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US10358435 (2019) BindingDB Entry DOI: 10.7270/Q2Q242M7
					More data for this Ligand-Target Pair
Phosphodiesterase (Macaca mulatta (Rhesus macaque))	BDBM355378 (2-(4-methoxybenzyl)-N-[(1R)-2- methyl-1-{4- [(trif...) Show SMILES COc1ccc(Cc2nc(cc(=O)[nH]2)C(=O)N[C@H](C(C)C)c2ccc(SC(F)(F)F)cc2)cc1 |r| Show InChI	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.960	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD R & D (China) Co. LTD. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US9815796 (2017) BindingDB Entry DOI: 10.7270/Q2V69MQQ
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM355418 (N-{(1R)-2,2-dimethyl-1-[4- (trifluoromethoxy)pheny...) Show SMILES COc1ccc(Cc2nc(cc(=O)[nH]2)C(=O)N[C@@H](c2ccc(OC(F)(F)F)cc2)C(C)(C)C)cc1F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.990	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD R & D (China) Co. LTD. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US9815796 (2017) BindingDB Entry DOI: 10.7270/Q2V69MQQ
					More data for this Ligand-Target Pair
Phosphodiesterase (Macaca mulatta (Rhesus macaque))	BDBM355153 (2-cyclopropyl-N-[(1R)-1-{3-fluoro-4- [(trifluorome...) Show SMILES CC(C)[C@@H](NC(=O)c1cc(=O)[nH]c(n1)C1CC1)c1ccc(SC(F)(F)F)c(F)c1 |r| Show InChI	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.990	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD R & D (China) Co. LTD. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US9815796 (2017) BindingDB Entry DOI: 10.7270/Q2V69MQQ
					More data for this Ligand-Target Pair
Phosphodiesterase (Macaca mulatta (Rhesus macaque))	BDBM355169 (N-[(1R)-1-{3-fluoro-4- [(trifluoromethyl)sulfanyl]...) Show SMILES C[C@@H](NC(=O)c1cc(=O)[nH]c(n1)-c1ncccn1)c1ccc(SC(F)(F)F)c(F)c1 |r| Show InChI	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD R & D (China) Co. LTD. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US9815796 (2017) BindingDB Entry DOI: 10.7270/Q2V69MQQ
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM355416 (N-[(1R)-2,2-dimethyl-1-{4- [(trifluoromethyl)sulfa...) Show SMILES COc1ccc(Cc2nc(cc(=O)[nH]2)C(=O)N[C@@H](c2ccc(SC(F)(F)F)cc2)C(C)(C)C)cc1F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD R & D (China) Co. LTD. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US9815796 (2017) BindingDB Entry DOI: 10.7270/Q2V69MQQ
					More data for this Ligand-Target Pair

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