Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Tyrosine-protein kinase SYK | ||
Ligand | BDBM60650 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Homogeneous Time-Resolved Fluorescence (HTRF) Assay | ||
pH | 7.5±n/a | ||
Temperature | 298.15±n/a K | ||
IC50 | 1±n/a nM | ||
Comments | extracted | ||
Citation | Deschenes, D; Altman, MD; Ellis, JM; Fischer, C; Haidle, AM; Kattar, SD; Northrup, AB; Schell, AJ; Smith, GF; Taoka, BM; Bienstock, C; Di Francesco, ME; Donofrio, A; Peterson, S; Spencer, KB; Jewell, JP; Ali, A; Bennett, DJ; Dang, Q; Wai, J Bipyridylaminopyridines as Syk inhibitors US Patent US9145391 Publication Date 9/29/2015 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase SYK | |||
Name: | Tyrosine-protein kinase SYK | ||
Synonyms: | KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk) | ||
Type: | Enzyme | ||
Mol. Mass.: | 72079.99 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P43405 | ||
Residue: | 635 | ||
Sequence: |
| ||
BDBM60650 | |||
n/a | |||
Name | BDBM60650 | ||
Synonyms: | US9145391, 23 | ||
Type | n/a | ||
Emp. Form. | C28H35F2N5O2 | ||
Mol. Mass. | 511.6066 | ||
SMILES | CN=C.[H][C@@]1(CC[C@H](CO)CC1)C(C)(O)c1ccc(cn1)-c1cc(C)cc(Nc2cc(ccn2)C(F)F)n1 |r,wD:4.2,7.6,(6.64,-4.64,;7.41,-3.31,;6.64,-1.97,;-4.95,-.87,;-3.62,-1.64,;-3.62,-.1,;-2.28,.67,;-.95,-.1,;.39,.67,;1.72,-.1,;-.95,-1.64,;-2.28,-2.41,;-4.95,-2.41,;-3.62,-3.18,;-4.95,-3.95,;-6.28,-1.64,;-7.62,-2.41,;-8.95,-1.64,;-8.95,-.1,;-7.62,.67,;-6.28,-.1,;-10.28,.67,;-11.62,-.1,;-12.95,.67,;-14.29,-.1,;-12.95,2.21,;-11.62,2.98,;-11.62,4.52,;-10.28,5.29,;-8.95,4.52,;-7.62,5.29,;-7.62,6.83,;-8.95,7.6,;-10.28,6.83,;-6.28,4.52,;-4.95,5.29,;-6.27,2.92,;-10.28,2.21,)| | ||
Structure |