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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase SYK | ||
| Ligand | BDBM182068 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Homogeneous Time-Resolved Fluorescence (HTRF) Assay | ||
| pH | 7.5±n/a | ||
| Temperature | 298.15±n/a K | ||
| IC50 | 1±n/a nM | ||
| Comments | extracted | ||
| Citation |  Deschenes, D; Altman, MD; Ellis, JM; Fischer, C; Haidle, AM; Kattar, SD; Northrup, AB; Schell, AJ; Smith, GF; Taoka, BM; Bienstock, C; Di Francesco, ME; Donofrio, A; Peterson, S; Spencer, KB; Jewell, JP; Ali, A; Bennett, DJ; Dang, Q; Wai, J Bipyridylaminopyridines as Syk inhibitors US Patent US9145391 Publication Date 9/29/2015 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase SYK | |||
| Name: | Tyrosine-protein kinase SYK | ||
| Synonyms: | KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 72079.99 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P43405 | ||
| Residue: | 635 | ||
| Sequence: |
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| BDBM182068 | |||
| n/a | |||
| Name | BDBM182068 | ||
| Synonyms: | US9145391, 1-36 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C28H30F2N4O3 | ||
| Mol. Mass. | 508.5596 | ||
| SMILES | CC(=O)C(C)(C1CCC(CC1)C(O)=O)c1ccc(cn1)-c1cc(C)cc(Nc2cc(ccn2)C(F)F)n1 |(2.04,-3.23,;1.27,-1.9,;2.04,-.56,;-.27,-1.9,;-1.81,-1.9,;-.27,-.36,;1.06,.41,;1.06,1.95,;-.27,2.72,;-1.6,1.95,;-1.6,.41,;-.27,4.26,;1.06,5.03,;-1.6,5.03,;-.27,-3.44,;1.06,-4.21,;1.06,-5.75,;-.27,-6.52,;-1.6,-5.75,;-1.6,-4.21,;-.27,-8.06,;1.06,-8.83,;1.06,-10.37,;2.4,-11.14,;-.27,-11.14,;-1.6,-10.37,;-2.94,-11.14,;-4.27,-10.37,;-4.27,-8.83,;-5.6,-8.06,;-6.94,-8.83,;-6.94,-10.37,;-5.6,-11.14,;-5.6,-6.52,;-6.94,-5.75,;-4.23,-5.71,;-1.6,-8.83,)| | ||
| Structure | 
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