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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase SYK | ||
| Ligand | BDBM182089 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Homogeneous Time-Resolved Fluorescence (HTRF) Assay | ||
| pH | 7.5±n/a | ||
| Temperature | 298.15±n/a K | ||
| IC50 | 1±n/a nM | ||
| Comments | extracted | ||
| Citation |  Deschenes, D; Altman, MD; Ellis, JM; Fischer, C; Haidle, AM; Kattar, SD; Northrup, AB; Schell, AJ; Smith, GF; Taoka, BM; Bienstock, C; Di Francesco, ME; Donofrio, A; Peterson, S; Spencer, KB; Jewell, JP; Ali, A; Bennett, DJ; Dang, Q; Wai, J Bipyridylaminopyridines as Syk inhibitors US Patent US9145391 Publication Date 9/29/2015 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase SYK | |||
| Name: | Tyrosine-protein kinase SYK | ||
| Synonyms: | KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 72079.99 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P43405 | ||
| Residue: | 635 | ||
| Sequence: |
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| BDBM182089 | |||
| n/a | |||
| Name | BDBM182089 | ||
| Synonyms: | US9145391, 2-24 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H24F3N5O2 | ||
| Mol. Mass. | 471.4749 | ||
| SMILES | Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1ccc(NC2CCC(CC2)C(O)=O)nc1 |(-11.08,-4.01,;-10.31,-2.67,;-11.08,-1.34,;-10.31,-.01,;-11.08,1.33,;-10.31,2.66,;-8.76,2.66,;-7.99,3.99,;-8.76,5.33,;-10.31,5.33,;-11.08,3.99,;-6.45,3.99,;-5.68,5.33,;-5.64,2.62,;-4.91,3.99,;-8.76,-.01,;-7.99,-1.34,;-8.76,-2.67,;-6.45,-1.34,;-5.68,-2.67,;-4.14,-2.67,;-3.37,-1.34,;-2.41,.38,;-.87,.38,;-.1,1.72,;1.44,1.72,;2.26,.39,;1.44,-.95,;-.1,-.95,;3.8,.39,;4.57,-.95,;4.57,1.72,;-4.14,-.01,;-5.68,-.01,)| | ||
| Structure | 
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