Reaction Details | |||
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Target | Tyrosine-protein kinase SYK | ||
Ligand | BDBM182238 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Homogeneous Time-Resolved Fluorescence (HTRF) Assay | ||
pH | 7.5±n/a | ||
Temperature | 298.15±n/a K | ||
IC50 | 1±n/a nM | ||
Comments | extracted | ||
Citation | Deschenes, D; Altman, MD; Ellis, JM; Fischer, C; Haidle, AM; Kattar, SD; Northrup, AB; Schell, AJ; Smith, GF; Taoka, BM; Bienstock, C; Di Francesco, ME; Donofrio, A; Peterson, S; Spencer, KB; Jewell, JP; Ali, A; Bennett, DJ; Dang, Q; Wai, J Bipyridylaminopyridines as Syk inhibitors US Patent US9145391 Publication Date 9/29/2015 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase SYK | |||
Name: | Tyrosine-protein kinase SYK | ||
Synonyms: | KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk) | ||
Type: | Enzyme | ||
Mol. Mass.: | 72079.99 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P43405 | ||
Residue: | 635 | ||
Sequence: |
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BDBM182238 | |||
n/a | |||
Name | BDBM182238 | ||
Synonyms: | US9145391, 10 | ||
Type | Small organic molecule | ||
Emp. Form. | C25H25F3N4O2 | ||
Mol. Mass. | 470.4868 | ||
SMILES | Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1ccc(C[C@H]2CC[C@@H](CC2)C(O)=O)nc1 |r,wU:23.24,wD:26.31,(2.67,7.34,;1.33,8.11,;,7.34,;-1.33,8.11,;-2.67,7.34,;-4,8.11,;-4,9.65,;-5.33,10.42,;-6.67,9.65,;-6.67,8.11,;-5.33,7.34,;-5.33,11.96,;-6.67,12.73,;-4,12.73,;-5.33,13.5,;-1.33,9.65,;,10.42,;1.33,9.65,;,11.96,;-1.33,12.73,;-1.33,14.27,;,15.04,;,16.58,;1.33,17.35,;1.33,18.89,;2.67,19.66,;4,18.89,;4,17.35,;2.67,16.58,;5.33,19.66,;6.67,18.89,;5.33,21.2,;1.33,14.27,;1.33,12.73,)| | ||
Structure |