| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein kinase SYK |
|---|
| Ligand | BDBM182810 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Syk Kinase Inhibition Assay |
|---|
| pH | 7.5±n/a |
|---|
| Temperature | 298.15±n/a K |
|---|
| IC50 | 0.29±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Sakamoto, T; Mita, T; Shibata, K; Ogino, Y; Komatani, H 1,2,4-triazine-6-carboxamide derivative US Patent US9145414 Publication Date 9/29/2015 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein kinase SYK |
|---|
| Name: | Tyrosine-protein kinase SYK |
|---|
| Synonyms: | KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 72079.99 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P43405 |
|---|
| Residue: | 635 |
|---|
| Sequence: | MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK
AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF
EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ
IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL
VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK
PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP
KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE
ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM
GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA
PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE
MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
|
|
|
|---|
| BDBM182810 |
|---|
| n/a |
|---|
| Name | BDBM182810 |
|---|
| Synonyms: | US9145414, 258 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H27N9O2 |
|---|
| Mol. Mass. | 461.5196 |
|---|
| SMILES | COC[C@H](N)[C@@H](C)Nc1nnc(C(N)=O)c(Nc2cc(-c3ccccc3)c3nn(C)cc3c2)n1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
