Reaction Details |
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Target | Sterol O-acyltransferase 1 |
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Ligand | BDBM182847 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Inhibition Assay |
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IC50 | 450±n/a nM |
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Citation | Chang, T; Chang, CC; Shibuya, Y; Bryleva, E; Murphy, S; Rogers, MA Method for selectively inhibiting ACAT1 in the treatment of alzheimer's disease US Patent US9149492 Publication Date 10/6/2015 |
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More Info.: | Get all data from this article, Assay Method |
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Sterol O-acyltransferase 1 |
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Name: | Sterol O-acyltransferase 1 |
Synonyms: | ACACT | ACACT1 | ACAT | ACAT1 | Acetyl-CoA acetyltransferase, mitochondrial | Acyl coenzyme A:cholesterol acyltransferase 1 | Acyl-CoA: cholesterol acyltransferase (ACAT) | Acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) | Cholesterol acyltransferase 1 | SOAT | SOAT1 | SOAT1_HUMAN | STAT |
Type: | Multi-pass membrane protein may form homo- or heterodimers. |
Mol. Mass.: | 64751.94 |
Organism: | Homo sapiens (Human) |
Description: | P35610 |
Residue: | 550 |
Sequence: | MVGEEKMSLRNRLSKSRENPEEDEDQRNPAKESLETPSNGRIDIKQLIAKKIKLTAEAEE
LKPFFMKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSVLEGEKNNHRAKDLRAPPEQGK
IFIARRSLLDELLEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFSLLSYAFGK
FPTVVWTWWIMFLSTFSVPYFLFQHWATGYSKSSHPLIRSLFHGFLFMIFQIGVLGFGPT
YVVLAYTLPPASRFIIIFEQIRFVMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYF
LFAPTLIYRDSYPRNPTVRWGYVAMKFAQVFGCFFYVYYIFERLCAPLFRNIKQEPFSAR
VLVLCVFNSILPGVLILFLTFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTW
NVVVHDWLYYYAYKDFLWFFSKRFKSAAMLAVFAVSAVVHEYALAVCLSFFYPVLFVLFM
FFGMAFNFIVNDSRKKPIWNVLMWTSLFLGNGVLLCFYSQEWYARQHCPLKNPTFLDYVR
PRSWTCRYVF
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BDBM182847 |
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n/a |
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Name | BDBM182847 |
Synonyms: | US9149492, K-604 |
Type | Small organic molecule |
Emp. Form. | C23H30N6OS3 |
Mol. Mass. | 502.719 |
SMILES | CSc1cc(C)nc(SC)c1NC(=O)CN1CCN(CCSc2nc3ccccc3[nH]2)CC1 |
Structure |
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