Reaction Details | |||
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Target | Leucine-rich repeat serine/threonine-protein kinase 2 | ||
Ligand | BDBM185535 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Lantha Screen Technology Assay | ||
pH | 7.5±n/a | ||
IC50 | 40±n/a nM | ||
Comments | extracted | ||
Citation | Galatsis, P; Hayward, MM; Kormos, BL; Wager, TT; Zhang, L; Stepan, AF; Henderson, JL; Kurumbail, RG; Verhoest, PR 4-(substituted amino)-7H-pyrrolo[2,3-d] pyrimidines as LRRK2 inhibitors US Patent US9156845 Publication Date 10/13/2015 | ||
More Info.: | Get all data from this article, Assay Method | ||
Leucine-rich repeat serine/threonine-protein kinase 2 | |||
Name: | Leucine-rich repeat serine/threonine-protein kinase 2 | ||
Synonyms: | Dardarin | LRRK2 | LRRK2_HUMAN | Leucine-Rich Repeat Kinase 2 Protein (LRRK2) | Leucine-rich repeat serine/threonine-protein kinase 2 | Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) | PARK8 | ||
Type: | Protein | ||
Mol. Mass.: | 286113.20 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q5S007 | ||
Residue: | 2527 | ||
Sequence: |
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BDBM185535 | |||
n/a | |||
Name | BDBM185535 | ||
Synonyms: | US9156845, 189 | ||
Type | Small organic molecule | ||
Emp. Form. | C15H15FN4O | ||
Mol. Mass. | 286.3042 | ||
SMILES | COc1cccc(F)c1-c1c[nH]c2ncnc(N(C)C)c12 |(4.3,-1.64,;2.81,-1.24,;2.41,.25,;3.5,1.34,;3.1,2.83,;1.61,3.23,;.53,2.14,;-.96,2.54,;.92,.65,;-.17,-.44,;.74,-1.69,;-.17,-2.93,;-1.63,-2.46,;-2.96,-3.23,;-4.3,-2.46,;-4.3,-.92,;-2.96,-.15,;-2.96,1.39,;-1.63,2.16,;-4.3,2.16,;-1.63,-.92,)| | ||
Structure |