Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S] | ||
| Ligand | BDBM185535 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Lantha Screen Technology Assay | ||
| pH | 7.5±n/a | ||
| IC50 | 27±n/a nM | ||
| Comments | extracted | ||
| Citation |  Galatsis, P; Hayward, MM; Kormos, BL; Wager, TT; Zhang, L; Stepan, AF; Henderson, JL; Kurumbail, RG; Verhoest, PR 4-(substituted amino)-7H-pyrrolo[2,3-d] pyrimidines as LRRK2 inhibitors US Patent US9156845 Publication Date 10/13/2015 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S] | |||
| Name: | Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S] | ||
| Synonyms: | LRRK2 | LRRK2 G2019S | LRRK2_HUMAN | Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (G2019S) | Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S) | Leucine-rich repeat serine/threonine-protein kinase 2 G2019S | PARK8 | ||
| Type: | n/a | ||
| Mol. Mass.: | 286143.23 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q5S007(G2019S) | ||
| Residue: | 2527 | ||
| Sequence: |
| ||
| BDBM185535 | |||
| n/a | |||
| Name | BDBM185535 | ||
| Synonyms: | US9156845, 189 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C15H15FN4O | ||
| Mol. Mass. | 286.3042 | ||
| SMILES | COc1cccc(F)c1-c1c[nH]c2ncnc(N(C)C)c12 |(4.3,-1.64,;2.81,-1.24,;2.41,.25,;3.5,1.34,;3.1,2.83,;1.61,3.23,;.53,2.14,;-.96,2.54,;.92,.65,;-.17,-.44,;.74,-1.69,;-.17,-2.93,;-1.63,-2.46,;-2.96,-3.23,;-4.3,-2.46,;-4.3,-.92,;-2.96,-.15,;-2.96,1.39,;-1.63,2.16,;-4.3,2.16,;-1.63,-.92,)| | ||
| Structure | 
| ||