Reaction Details | |||
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Target | 11-beta-hydroxysteroid dehydrogenase 1 | ||
Ligand | BDBM186114 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Scintillation Proximity Assay | ||
Temperature | 298.15±n/a K | ||
IC50 | 1.08±n/a nM | ||
Comments | extracted | ||
Citation | Claremon, DA; Tice, CM; Zhuang, L; Leftheris, K; Ye, Y; Singh, SB Carbamate and urea inhibitors of 11β-hydroxysteroid dehydrogenase 1 US Patent US9163012 Publication Date 10/20/2015 | ||
More Info.: | Get all data from this article, Assay Method | ||
11-beta-hydroxysteroid dehydrogenase 1 | |||
Name: | 11-beta-hydroxysteroid dehydrogenase 1 | ||
Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 32409.16 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P28845 | ||
Residue: | 292 | ||
Sequence: |
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BDBM186114 | |||
n/a | |||
Name | BDBM186114 | ||
Synonyms: | US9163012, 32 | ||
Type | Small organic molecule | ||
Emp. Form. | C24H30N4O3 | ||
Mol. Mass. | 422.52 | ||
SMILES | Cn1c(nc2ccccc12)C1CCCN1C(=O)OC1C2CC3CC1CC(C3)(C2)C(N)=O |TLB:18:19:26:24.23.22,17:18:24:26.21.22,THB:18:23:26:19.20.27,20:19:24:26.21.22,20:21:24:19.18.27,(7.18,.9,;5.85,.13,;4.38,.6,;3.48,-.64,;4.38,-1.89,;4.06,-3.4,;5.21,-4.43,;6.67,-3.95,;6.99,-2.44,;5.85,-1.41,;3.61,1.94,;4.52,3.18,;3.61,4.43,;2.15,3.95,;2.15,2.41,;.81,1.64,;.81,.1,;-.52,2.41,;-1.85,1.64,;-1.85,.1,;-2.75,-1.82,;-3.95,-1.16,;-3.94,1.24,;-3.18,2.41,;-4.51,1.64,;-4.51,.1,;-5.35,-1.8,;-3.18,-.67,;-5.85,-.67,;-7.18,.1,;-5.85,-2.21,)| | ||
Structure |