| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex |
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| Ligand | BDBM31040 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| pH | 7±n/a |
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| IC50 | <40±n/a nM |
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| Comments | extracted |
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| Citation |  Wong, C; Wu, Y Compounds and methods for treating tuberculosis infection US Patent US9073941 Publication Date 7/7/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex |
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| Name: | Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex |
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| Synonyms: | ODP2_MYCTU | Pyruvate dehydrogenase (PDH) | dlaT | sucB |
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| Type: | Enzyme |
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| Mol. Mass.: | 57069.35 |
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| Organism: | Mycobacterium tuberculosis |
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| Description: | P9WIS7 |
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| Residue: | 553 |
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| Sequence: | MAFSVQMPALGESVTEGTVTRWLKQEGDTVELDEPLVEVSTDKVDTEIPSPAAGVLTKII
AQEDDTVEVGGELAVIGDAKDAGEAAAPAPEKVPAAQPESKPAPEPPPVQPTSGAPAGGD
AKPVLMPELGESVTEGTVIRWLKKIGDSVQVDEPLVEVSTDKVDTEIPSPVAGVLVSISA
DEDATVPVGGELARIGVAADIGAAPAPKPAPKPVPEPAPTPKAEPAPSPPAAQPAGAAEG
APYVTPLVRKLASENNIDLAGVTGTGVGGRIRKQDVLAAAEQKKRAKAPAPAAQAAAAPA
PKAPPAPAPALAHLRGTTQKASRIRQITANKTRESLQATAQLTQTHEVDMTKIVGLRARA
KAAFAEREGVNLTFLPFFAKAVIDALKIHPNINASYNEDTKEITYYDAEHLGFAVDTEQG
LLSPVIHDAGDLSLAGLARAIADIAARARSGNLKPDELSGGTFTITNIGSQGALFDTPIL
VPPQAAMLGTGAIVKRPRVVVDASGNESIGVRSVCYLPLTYDHRLIDGADAGRFLTTIKH
RLEEGAFEADLGL
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| BDBM31040 |
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| n/a |
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| Name | BDBM31040 |
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| Synonyms: | 1-Ethyl-6-methyl-3-phenyl-1H-pyrimido[5,4-e][1,2,4]triazine-5,7-dione | 1-ethyl-6-methyl-3-phenyl-pyrimido[5,4-e][1,2,4]triazine-5,7-dione | 1-ethyl-6-methyl-3-phenyl-pyrimido[5,4-e][1,2,4]triazine-5,7-quinone | 1-ethyl-6-methyl-3-phenylpyrimido[5,4-e][1,2,4]triazine-5,7-dione | MLS000027832 | SMR000008919 | US9073941, 602 | cid_647501 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H13N5O2 |
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| Mol. Mass. | 283.2853 |
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| SMILES | CCn1nc(nc2c1nc(=O)n(C)c2=O)-c1ccccc1 |
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| Structure | 
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