| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex |
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| Ligand | BDBM34905 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| pH | 7±n/a |
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| IC50 | <40±n/a nM |
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| Comments | extracted |
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| Citation |  Wong, C; Wu, Y Compounds and methods for treating tuberculosis infection US Patent US9073941 Publication Date 7/7/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex |
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| Name: | Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex |
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| Synonyms: | ODP2_MYCTU | Pyruvate dehydrogenase (PDH) | dlaT | sucB |
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| Type: | Enzyme |
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| Mol. Mass.: | 57069.35 |
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| Organism: | Mycobacterium tuberculosis |
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| Description: | P9WIS7 |
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| Residue: | 553 |
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| Sequence: | MAFSVQMPALGESVTEGTVTRWLKQEGDTVELDEPLVEVSTDKVDTEIPSPAAGVLTKII
AQEDDTVEVGGELAVIGDAKDAGEAAAPAPEKVPAAQPESKPAPEPPPVQPTSGAPAGGD
AKPVLMPELGESVTEGTVIRWLKKIGDSVQVDEPLVEVSTDKVDTEIPSPVAGVLVSISA
DEDATVPVGGELARIGVAADIGAAPAPKPAPKPVPEPAPTPKAEPAPSPPAAQPAGAAEG
APYVTPLVRKLASENNIDLAGVTGTGVGGRIRKQDVLAAAEQKKRAKAPAPAAQAAAAPA
PKAPPAPAPALAHLRGTTQKASRIRQITANKTRESLQATAQLTQTHEVDMTKIVGLRARA
KAAFAEREGVNLTFLPFFAKAVIDALKIHPNINASYNEDTKEITYYDAEHLGFAVDTEQG
LLSPVIHDAGDLSLAGLARAIADIAARARSGNLKPDELSGGTFTITNIGSQGALFDTPIL
VPPQAAMLGTGAIVKRPRVVVDASGNESIGVRSVCYLPLTYDHRLIDGADAGRFLTTIKH
RLEEGAFEADLGL
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| BDBM34905 |
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| n/a |
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| Name | BDBM34905 |
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| Synonyms: | 1,6-dimethyl-3-propyl-pyrimido[5,4-e][1,2,4]triazine-5,7-dione | 1,6-dimethyl-3-propyl-pyrimido[5,4-e][1,2,4]triazine-5,7-quinone | 1,6-dimethyl-3-propylpyrimido[5,4-e][1,2,4]triazine-5,7-dione | MLS000718932 | SMR000291200 | US9073941, 617 | cid_3164059 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H13N5O2 |
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| Mol. Mass. | 235.2425 |
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| SMILES | CCCc1nn(C)c2nc(=O)n(C)c(=O)c2n1 |
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| Structure | 
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