| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex |
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| Ligand | BDBM32062 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| pH | 7±n/a |
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| IC50 | >5000±n/a nM |
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| Comments | extracted |
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| Citation |  Wong, C; Wu, Y Compounds and methods for treating tuberculosis infection US Patent US9073941 Publication Date 7/7/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex |
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| Name: | Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex |
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| Synonyms: | ODP2_MYCTU | Pyruvate dehydrogenase (PDH) | dlaT | sucB |
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| Type: | Enzyme |
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| Mol. Mass.: | 57069.35 |
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| Organism: | Mycobacterium tuberculosis |
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| Description: | P9WIS7 |
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| Residue: | 553 |
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| Sequence: | MAFSVQMPALGESVTEGTVTRWLKQEGDTVELDEPLVEVSTDKVDTEIPSPAAGVLTKII
AQEDDTVEVGGELAVIGDAKDAGEAAAPAPEKVPAAQPESKPAPEPPPVQPTSGAPAGGD
AKPVLMPELGESVTEGTVIRWLKKIGDSVQVDEPLVEVSTDKVDTEIPSPVAGVLVSISA
DEDATVPVGGELARIGVAADIGAAPAPKPAPKPVPEPAPTPKAEPAPSPPAAQPAGAAEG
APYVTPLVRKLASENNIDLAGVTGTGVGGRIRKQDVLAAAEQKKRAKAPAPAAQAAAAPA
PKAPPAPAPALAHLRGTTQKASRIRQITANKTRESLQATAQLTQTHEVDMTKIVGLRARA
KAAFAEREGVNLTFLPFFAKAVIDALKIHPNINASYNEDTKEITYYDAEHLGFAVDTEQG
LLSPVIHDAGDLSLAGLARAIADIAARARSGNLKPDELSGGTFTITNIGSQGALFDTPIL
VPPQAAMLGTGAIVKRPRVVVDASGNESIGVRSVCYLPLTYDHRLIDGADAGRFLTTIKH
RLEEGAFEADLGL
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| BDBM32062 |
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| n/a |
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| Name | BDBM32062 |
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| Synonyms: | MLS000054842 | N-(1-butyl-3-cyano-2-pyrrolo[3,2-b]quinoxalinyl)benzamide | N-(1-butyl-3-cyano-pyrrolo[3,2-b]quinoxalin-2-yl)benzamide | N-(1-butyl-3-cyanopyrrolo[3,2-b]quinoxalin-2-yl)benzamide | SMR000060333 | US9045483, 3 | US9073941, 1003 | cid_1910302 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H19N5O |
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| Mol. Mass. | 369.4192 |
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| SMILES | CCCCn1c(NC(=O)c2ccccc2)c(C#N)c2nc3ccccc3nc12 |
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| Structure | 
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