Reaction Details | |||
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Target | Tyrosine-protein kinase BTK | ||
Ligand | BDBM288460 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Btk Enzyme Activity Assay | ||
IC50 | 0.390±n/a nM | ||
Citation | Liu, J; Kozlowski, JA; Alhassan, A; Boga, SB; Gao, X; Guiadeen, DG; Wang, J; Yu, W; Cai, J; Liu, S; Wang, D; Wu, H; Yang, C Benzamide imidazopyrazine Btk inhibitors US Patent US10087188 Publication Date 10/2/2018 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase BTK | |||
Name: | Tyrosine-protein kinase BTK | ||
Synonyms: | AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK) | ||
Type: | Enzyme | ||
Mol. Mass.: | 76289.95 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q06187 | ||
Residue: | 659 | ||
Sequence: |
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BDBM288460 | |||
n/a | |||
Name | BDBM288460 | ||
Synonyms: | 5-[8-amino-1-(2- ethoxy-4-{[4- (trifluoromethyl) pyridin-2- yl]carbamoyl}phenyl) imidazo[1,5-a]pyrazin- 3- yl]bicyclo[3.2.2] nonane-1-carboxylic acid | US10087188, Example 67 | ||
Type | Small organic molecule | ||
Emp. Form. | C31H31F3N6O4 | ||
Mol. Mass. | 608.6108 | ||
SMILES | CCOc1cc(ccc1-c1nc(n2ccnc(N)c12)C12CCC(CC1)(CCC2)C(O)=O)C(=O)Nc1cc(ccn1)C(F)(F)F |(3.05,-3.51,;1.96,-2.42,;2.36,-.93,;1.27,.16,;1.67,1.64,;.58,2.73,;-.91,2.33,;-1.31,.85,;-.22,-.24,;-.62,-1.73,;.29,-2.98,;-.62,-4.22,;-2.08,-3.75,;-3.42,-4.52,;-4.75,-3.75,;-4.75,-2.21,;-3.42,-1.44,;-3.42,.1,;-2.08,-2.21,;-.22,-5.71,;-1.31,-6.8,;-.91,-8.29,;.58,-8.68,;1.67,-7.59,;1.27,-6.11,;2.31,-8.29,;2.31,-6.75,;1.32,-5.71,;.18,-10.17,;-1.31,-10.57,;1.27,-11.26,;.98,4.22,;-.11,5.31,;2.46,4.62,;2.86,6.11,;1.77,7.2,;2.17,8.68,;3.66,9.08,;4.75,7.99,;4.35,6.51,;1.08,9.77,;-.4,9.37,;1.48,11.26,;2.57,10.17,)| | ||
Structure |