Reaction Details | |||
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Target | Interleukin-1 receptor-associated kinase 4 | ||
Ligand | BDBM187584 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Inhibition Assay | ||
pH | 7.2±n/a | ||
IC50 | 1.4±n/a nM | ||
Citation | Santella, JB; Kumar, SR; Duncia, JV; Gardner, DS; Paidi, VR; Nair, SK; Hynes, J; Wu, H; Murugesan, N; Sarkunam, K; Arunachalam, P Heteroaryl substituted nicotinamide compounds US Patent US9169252 Publication Date 10/27/2015 | ||
More Info.: | Get all data from this article, Solution Info, Assay Method | ||
Interleukin-1 receptor-associated kinase 4 | |||
Name: | Interleukin-1 receptor-associated kinase 4 | ||
Synonyms: | IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64 | ||
Type: | Protein | ||
Mol. Mass.: | 51519.08 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q9NWZ3 | ||
Residue: | 460 | ||
Sequence: |
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BDBM187584 | |||
n/a | |||
Name | BDBM187584 | ||
Synonyms: | US9169252, 148 | ||
Type | Small organic molecule | ||
Emp. Form. | C25H31N7O2 | ||
Mol. Mass. | 461.5593 | ||
SMILES | CC(C)Nc1cc(ncc1C(=O)N[C@H]1CC[C@@H](CC1)C(C)(C)O)-n1ncc2cc(cnc12)C#N |r,wU:13.13,wD:16.20,(2.87,2.16,;1.54,2.93,;1.54,4.47,;.21,2.16,;.21,.62,;1.54,-.15,;1.54,-1.69,;.21,-2.46,;-1.13,-1.69,;-1.13,-.15,;-2.46,.62,;-2.46,2.16,;-3.8,-.15,;-5.13,.62,;-6.46,-.15,;-7.8,.62,;-7.8,2.16,;-6.46,2.93,;-5.13,2.16,;-9.13,2.93,;-9.13,4.47,;-10.46,2.16,;-10.46,3.7,;2.87,-2.46,;2.87,-4,;4.34,-4.47,;5.24,-3.23,;6.77,-3.07,;7.4,-1.66,;6.5,-.41,;4.96,-.57,;4.34,-1.98,;8.93,-1.5,;10.46,-1.34,)| | ||
Structure |