Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Interleukin-1 receptor-associated kinase 4 | ||
| Ligand | BDBM188919 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Kinase Assay | ||
| pH | 7.2±n/a | ||
| IC50 | <100±n/a nM | ||
| Comments | extracted | ||
| Citation |  McElroy, WT; Li, G; Ho, GD; Tan, Z; Paliwal, S; Seganish, WM; Tulshian, D; Lampe, J; Methot, JL; Zhou, H; Altman, MD; Zhu, L Amidopyrazole inhibitors of interleukin receptor-associated kinases US Patent US9169260 Publication Date 10/27/2015 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Interleukin-1 receptor-associated kinase 4 | |||
| Name: | Interleukin-1 receptor-associated kinase 4 | ||
| Synonyms: | IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64 | ||
| Type: | Protein | ||
| Mol. Mass.: | 51519.08 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q9NWZ3 | ||
| Residue: | 460 | ||
| Sequence: |
| ||
| BDBM188919 | |||
| n/a | |||
| Name | BDBM188919 | ||
| Synonyms: | US9169260, 185 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H24N8O | ||
| Mol. Mass. | 416.479 | ||
| SMILES | Cc1ccc(nc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCC(N)CC1 |(6.33,5.23,;5.24,4.14,;3.75,4.54,;2.66,3.45,;3.06,1.96,;4.55,1.56,;5.64,2.65,;1.97,.87,;1.97,-.67,;.51,-1.14,;-.4,.1,;.51,1.35,;.11,2.84,;-1.38,3.24,;-2.47,2.15,;-1.78,4.72,;-1.3,6.19,;-2.55,7.09,;-3.79,6.19,;-5.3,6.51,;-6.33,5.36,;-5.85,3.9,;-4.35,3.58,;-3.32,4.72,;.11,-2.63,;-1.38,-3.03,;-1.78,-4.52,;-.69,-5.61,;-1.09,-7.09,;.8,-5.21,;1.2,-3.72,)| | ||
| Structure | 
| ||