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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Interleukin-1 receptor-associated kinase 4 | ||
| Ligand | BDBM188986 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Kinase Assay | ||
| pH | 7.2±n/a | ||
| IC50 | <100±n/a nM | ||
| Comments | extracted | ||
| Citation |  McElroy, WT; Li, G; Ho, GD; Tan, Z; Paliwal, S; Seganish, WM; Tulshian, D; Lampe, J; Methot, JL; Zhou, H; Altman, MD; Zhu, L Amidopyrazole inhibitors of interleukin receptor-associated kinases US Patent US9169260 Publication Date 10/27/2015 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Interleukin-1 receptor-associated kinase 4 | |||
| Name: | Interleukin-1 receptor-associated kinase 4 | ||
| Synonyms: | IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64 | ||
| Type: | Protein | ||
| Mol. Mass.: | 51519.08 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q9NWZ3 | ||
| Residue: | 460 | ||
| Sequence: |
| ||
| BDBM188986 | |||
| n/a | |||
| Name | BDBM188986 | ||
| Synonyms: | US9169260, 252 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C29H36N8O3S | ||
| Mol. Mass. | 576.713 | ||
| SMILES | Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCN(CC1)C1CCC(CC1)NS(C)(=O)=O |(9.28,2.55,;7.79,2.15,;7.4,.66,;5.91,.26,;4.82,1.35,;5.22,2.84,;6.71,3.24,;3.33,.95,;2.86,-.51,;1.32,-.51,;.84,.95,;2.09,1.86,;2.09,3.4,;.75,4.17,;-.58,3.4,;.75,5.71,;2,6.61,;1.52,8.08,;-.02,8.08,;-1.05,9.22,;-2.55,8.9,;-3.03,7.44,;-2,6.29,;-.49,6.61,;.23,-1.6,;-1.26,-1.2,;-2.35,-2.29,;-1.95,-3.78,;-.46,-4.18,;.63,-3.09,;-3.04,-4.87,;-4.53,-4.47,;-5.62,-5.56,;-5.22,-7.04,;-3.73,-7.44,;-2.64,-6.35,;-6.31,-8.13,;-7.79,-7.74,;-8.19,-9.22,;-9.28,-7.34,;-7.4,-6.25,)| | ||
| Structure | 
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