Ki Summary

Reaction Details

Report a problem with these data

Target

Apoptosis regulator Bcl-2

Ligand

BDBM189754

Substrate/Competitor

n/a

Meas. Tech.

Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) Assay

Temperature

298.15±n/a K

<0.01±n/a nM

Comments

extracted

Citation

Bruncko, M; Ding, H; Doherty, GA; Elmore, SW; Hasvold, LA; Hexamer, L; Kunzer, AR; Song, X; Souers, AJ; Sullivan, GM; Tao, Z; Wang, GT; Wang, L; Wang, X; Wendt, MD; Mantei, RA; Hansen, TM Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases US Patent US9174982 Publication Date 11/3/2015

More Info.:

Get all data from this article, Assay Method

Apoptosis regulator Bcl-2

Name:

Apoptosis regulator Bcl-2

Synonyms:

Type:

Homodimer or heterodimer

Mol. Mass.:

26269.11

Organism:

Homo sapiens (Human)

Description:

P10415

Residue:

239

Sequence:

MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK

BDBM189754

n/a

Name

BDBM189754

Synonyms:

US10213433, Compound 324 | US11369599, Compound 324 | US20240043404, Example 324 | US9174982, 324

Type

Small organic molecule

Emp. Form.

C44H46ClF2N7O7S

Mol. Mass.

890.394

SMILES

O[C@H]1CC[C@H](CNc2ccc(cc2[N+]([O-])=O)S(=O)(=O)NC(=O)c2ccc(cc2Oc2cnc3[nH]ccc3c2)N2CCN(CC3=C(CCC(F)(F)C3)c3ccc(Cl)cc3)CC2)CC1 |wU:4.4,wD:1.0,t:47,(-11.34,6.22,;-9.8,6.22,;-9.03,4.89,;-7.49,4.89,;-6.72,6.22,;-5.18,6.22,;-4.41,7.56,;-2.87,7.56,;-2.1,6.22,;-.56,6.22,;.21,7.56,;-.56,8.89,;-2.1,8.89,;-2.87,10.22,;-2.1,11.56,;-4.41,10.22,;1.75,7.56,;1.75,9.1,;3.29,7.56,;1.75,6.02,;3.08,5.25,;4.42,6.02,;3.08,3.71,;4.42,2.94,;4.42,1.4,;3.08,.63,;1.75,1.4,;1.75,2.94,;.42,3.71,;-.92,2.94,;-.92,1.4,;-2.25,.63,;-3.58,1.4,;-5.05,.92,;-5.95,2.17,;-5.05,3.41,;-3.58,2.94,;-2.25,3.71,;3.08,-.91,;4.42,-1.68,;4.42,-3.22,;3.08,-3.99,;3.08,-5.53,;4.42,-6.3,;4.42,-7.84,;5.75,-8.61,;7.08,-7.84,;7.08,-6.3,;8.62,-6.25,;7.9,-5,;5.75,-5.53,;3.08,-8.61,;3.08,-10.15,;1.75,-10.92,;.42,-10.15,;-.92,-10.92,;.42,-8.61,;1.75,-7.84,;1.75,-3.22,;1.75,-1.68,;-7.49,7.56,;-9.03,7.56,)|

Structure