Ki Summary

Reaction Details

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Target

Apoptosis regulator Bcl-2

Ligand

BDBM189778

Substrate/Competitor

n/a

Meas. Tech.

Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) Assay

Temperature

298.15±n/a K

<0.01±n/a nM

Comments

extracted

Citation

Bruncko, M; Ding, H; Doherty, GA; Elmore, SW; Hasvold, LA; Hexamer, L; Kunzer, AR; Song, X; Souers, AJ; Sullivan, GM; Tao, Z; Wang, GT; Wang, L; Wang, X; Wendt, MD; Mantei, RA; Hansen, TM Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases US Patent US9174982 Publication Date 11/3/2015

More Info.:

Get all data from this article, Assay Method

Apoptosis regulator Bcl-2

Name:

Apoptosis regulator Bcl-2

Synonyms:

Type:

Homodimer or heterodimer

Mol. Mass.:

26269.11

Organism:

Homo sapiens (Human)

Description:

P10415

Residue:

239

Sequence:

MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK

BDBM189778

n/a

Name

BDBM189778

Synonyms:

US11369599, Compound 350 | US9174982, 350

Type

Small organic molecule

Emp. Form.

C45H49Cl2FN6O6S

Mol. Mass.

891.877

SMILES

CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3cnc(OCC4(F)CCC(O)CC4)c(Cl)c3)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccc(Cl)cc1 |c:57,(-2.44,-10.6,;-1.63,-9.3,;-3.17,-9.35,;-1.63,-7.76,;-.29,-6.99,;1.04,-7.76,;2.37,-6.99,;2.37,-5.45,;3.71,-4.68,;3.71,-3.14,;2.37,-2.37,;1.04,-3.14,;1.04,-4.68,;2.37,-.83,;3.71,-.06,;3.71,1.48,;2.37,2.25,;2.37,3.79,;1.04,4.56,;3.71,4.56,;5.04,3.79,;5.81,5.13,;4.27,2.46,;6.38,3.02,;6.38,1.48,;7.71,.71,;9.04,1.48,;10.38,.71,;10.38,-.83,;11.71,-1.6,;11.6,-.06,;13.25,-1.54,;14.07,-2.85,;13.34,-4.21,;14.16,-5.51,;11.8,-4.26,;10.99,-2.96,;9.04,3.02,;10.38,3.79,;7.71,3.79,;1.04,1.48,;-.29,2.25,;-1.63,1.48,;-1.63,-.06,;-2.96,-.83,;-4.29,-.06,;-5.76,-.53,;-6.66,.71,;-5.76,1.96,;-4.29,1.48,;-2.96,2.25,;1.04,-.06,;1.04,-9.3,;-.29,-10.07,;2.37,-10.07,;3.71,-9.3,;5.04,-10.07,;5.04,-11.61,;6.38,-12.38,;3.71,-12.38,;2.37,-11.61,)|

Structure