| Reaction Details |
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 | Report a problem with these data |
| Target | Neutrophil elastase |
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| Ligand | BDBM189818 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| pH | 7.4±n/a |
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| Temperature | 310.15±n/a K |
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| IC50 | <0.3±n/a nM |
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| Comments | extracted |
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| Citation |  Von Nussbaum, F; Karthaus, D; Anlauf, S; Delbeck, M; Li, VM; Meibom, D; Lustig, K; Schamberger, J 4-(4-cyano-2-thioaryl)dihydropyrimidinones and use thereof US Patent US9174997 Publication Date 11/3/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| Neutrophil elastase |
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| Name: | Neutrophil elastase |
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| Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
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| Type: | Enzyme |
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| Mol. Mass.: | 28532.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08246 |
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| Residue: | 267 |
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| Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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| BDBM189818 |
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| n/a |
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| Name | BDBM189818 |
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| Synonyms: | US9174997, 27 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H17F3N4O5S2 |
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| Mol. Mass. | 538.519 |
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| SMILES | CC1=C([N+]#[C-])[C@H](N(C(=O)N1c1cccc(c1)C(F)(F)F)S(C)(=O)=O)c1ccc(cc1S(C)(=O)=O)C#N |r,c:1| |
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| Structure | 
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