Reaction Details | |||
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Target | Histone-lysine N-methyltransferase EZH2 [A677G] | ||
Ligand | BDBM172167 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Inhibition Assay | ||
IC50 | 3.1±n/a nM | ||
Citation | Kuntz, KW; Knutson, SK; Wigle, TJ Inhibitors of human EZH2, and methods of use thereof US Patent US9175331 Publication Date 11/3/2015 | ||
More Info.: | Get all data from this article, Assay Method | ||
Histone-lysine N-methyltransferase EZH2 [A677G] | |||
Name: | Histone-lysine N-methyltransferase EZH2 [A677G] | ||
Synonyms: | EZH2 | EZH2_HUMAN | Histone-lysine N-methyltransferase EZH2 (A677G) | KMT6 | ||
Type: | Protein | ||
Mol. Mass.: | 85381.87 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q15910[A677G] | ||
Residue: | 746 | ||
Sequence: |
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BDBM172167 | |||
n/a | |||
Name | BDBM172167 | ||
Synonyms: | EPZ008338 | US10155002, Compound 175 | US11052093, Compound 175 | US9090562, 175 | US9175331, 33 | ||
Type | Small organic molecule | ||
Emp. Form. | C31H42N6O2 | ||
Mol. Mass. | 530.7042 | ||
SMILES | CCN([C@H]1CC[C@@H](CC1)N(C)C)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1cnc(C)cn1 |r,wU:3.2,wD:6.9,(-2,5.78,;-3.33,5,;-3.33,3.47,;-4.67,2.69,;-4.67,1.15,;-6,.38,;-7.34,1.15,;-7.34,2.69,;-6,3.47,;-8.67,.38,;-10,1.15,;-8.67,-1.15,;-2,2.69,;-2,1.15,;-.67,.38,;.67,1.15,;.67,2.69,;2,3.47,;2,5,;3.33,2.69,;4.67,3.47,;6,2.69,;7.34,3.47,;7.34,5,;8.67,2.69,;8.67,1.15,;10,.38,;7.34,.38,;6,1.15,;4.67,.38,;-.67,3.47,;-.67,5,;-.67,-1.15,;-2,-1.93,;-2,-3.47,;-.67,-4.23,;-.67,-5.78,;.67,-3.47,;.67,-1.93,)| | ||
Structure |