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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Histone-lysine N-methyltransferase EZH2 [A677G] | ||
| Ligand | BDBM190206 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Inhibition Assay | ||
| IC50 | 2.8±n/a nM | ||
| Citation |  Kuntz, KW; Knutson, SK; Wigle, TJ Inhibitors of human EZH2, and methods of use thereof US Patent US9175331 Publication Date 11/3/2015 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Histone-lysine N-methyltransferase EZH2 [A677G] | |||
| Name: | Histone-lysine N-methyltransferase EZH2 [A677G] | ||
| Synonyms: | EZH2 | EZH2_HUMAN | Histone-lysine N-methyltransferase EZH2 (A677G) | KMT6 | ||
| Type: | Protein | ||
| Mol. Mass.: | 85381.87 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q15910[A677G] | ||
| Residue: | 746 | ||
| Sequence: |
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| BDBM190206 | |||
| n/a | |||
| Name | BDBM190206 | ||
| Synonyms: | EPZ008494 | US9175331, 37 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C28H41ClN4O2 | ||
| Mol. Mass. | 501.104 | ||
| SMILES | CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(Cl)cc(N(CC)[C@H]2CC[C@@H](CC2)N(C)C)c1C |r,wU:24.24,wD:27.31,(-4.67,-1.54,;-4.67,-3.08,;-3.33,-3.85,;-3.33,-5.39,;-4.67,-6.16,;-4.67,-7.7,;-6,-8.47,;-3.33,-8.47,;-2,-7.7,;-.67,-8.47,;-2,-6.16,;-.67,-5.39,;-.67,-3.85,;.67,-3.08,;2,-3.85,;.67,-1.54,;-.67,-.77,;-.67,.77,;-2,1.54,;.67,1.54,;2,.77,;3.33,1.54,;4.67,.77,;6,1.54,;3.33,3.08,;2,3.85,;2,5.39,;3.33,6.16,;4.67,5.39,;4.67,3.85,;3.33,7.7,;2,8.47,;4.67,8.47,;2,-.77,;3.33,-1.54,)| | ||
| Structure | 
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