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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Histone-lysine N-methyltransferase EZH2 [A687V] | ||
| Ligand | BDBM190188 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Inhibition Assay | ||
| IC50 | 4±n/a nM | ||
| Citation |  Kuntz, KW; Knutson, SK; Wigle, TJ Inhibitors of human EZH2, and methods of use thereof US Patent US9175331 Publication Date 11/3/2015 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Histone-lysine N-methyltransferase EZH2 [A687V] | |||
| Name: | Histone-lysine N-methyltransferase EZH2 [A687V] | ||
| Synonyms: | EZH2 | EZH2_HUMAN | Histone-lysine N-methyltransferase EZH2 (A687V) | KMT6 | ||
| Type: | Protein | ||
| Mol. Mass.: | 85395.90 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q15910[A687V] | ||
| Residue: | 746 | ||
| Sequence: |
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| BDBM190188 | |||
| n/a | |||
| Name | BDBM190188 | ||
| Synonyms: | EPZ007426 | US9175331, 15 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C28H38N4O2 | ||
| Mol. Mass. | 462.6269 | ||
| SMILES | CCN([C@H]1CC[C@@H](CC1)N(C)C)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)C#C |r,wU:3.2,wD:6.9,(-5.33,3.47,;-5.33,1.93,;-4,1.15,;-4,-.38,;-2.67,-1.15,;-2.67,-2.69,;-4,-3.47,;-5.33,-2.69,;-5.33,-1.15,;-4,-5,;-2.67,-5.78,;-5.33,-5.78,;-2.67,1.93,;-2.67,3.47,;-1.33,4.23,;,3.47,;,1.93,;1.33,1.15,;2.67,1.93,;1.33,-.38,;2.67,-1.15,;2.67,-2.69,;4,-3.47,;5.33,-2.69,;4,-5,;2.67,-5.78,;2.67,-7.31,;1.33,-5,;1.33,-3.47,;,-2.69,;-1.33,1.15,;-1.33,-.38,;-1.33,5.78,;-1.33,7.31,)| | ||
| Structure | 
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