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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Histone-lysine N-methyltransferase EZH2 [A687V] | ||
| Ligand | BDBM190189 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Inhibition Assay | ||
| IC50 | 7.1±n/a nM | ||
| Citation |  Kuntz, KW; Knutson, SK; Wigle, TJ Inhibitors of human EZH2, and methods of use thereof US Patent US9175331 Publication Date 11/3/2015 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Histone-lysine N-methyltransferase EZH2 [A687V] | |||
| Name: | Histone-lysine N-methyltransferase EZH2 [A687V] | ||
| Synonyms: | EZH2 | EZH2_HUMAN | Histone-lysine N-methyltransferase EZH2 (A687V) | KMT6 | ||
| Type: | Protein | ||
| Mol. Mass.: | 85395.90 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q15910[A687V] | ||
| Residue: | 746 | ||
| Sequence: |
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| BDBM190189 | |||
| n/a | |||
| Name | BDBM190189 | ||
| Synonyms: | EPZ007478 | US9175331, 17 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C29H41ClN4O2 | ||
| Mol. Mass. | 513.114 | ||
| SMILES | CCN([C@H]1CC[C@@H](CC1)N(C)C1CCC1)c1cc(Cl)cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r,wU:3.2,wD:6.9,(-6.67,.32,;-5.33,-.45,;-4,.32,;-2.67,-.45,;-1.33,.32,;,-.45,;,-1.99,;-1.33,-2.76,;-2.67,-1.99,;1.33,-2.76,;2.67,-1.99,;1.33,-4.3,;.24,-5.39,;1.33,-6.48,;2.42,-5.39,;-4,1.86,;-5.33,2.63,;-5.33,4.17,;-6.67,4.94,;-4,4.94,;-2.67,4.17,;-1.33,4.94,;-1.33,6.48,;,4.17,;1.33,4.94,;2.67,4.17,;4,4.94,;4,6.48,;5.33,4.17,;5.33,2.63,;6.67,1.86,;4,1.86,;2.67,2.63,;1.33,1.86,;-2.67,2.63,;-1.33,1.86,)| | ||
| Structure | 
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