Reaction Details | |||
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Target | Histone-lysine N-methyltransferase EZH2 [A687V] | ||
Ligand | BDBM190221 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Inhibition Assay | ||
IC50 | 13.2±n/a nM | ||
Citation | Kuntz, KW; Knutson, SK; Wigle, TJ Inhibitors of human EZH2, and methods of use thereof US Patent US9175331 Publication Date 11/3/2015 | ||
More Info.: | Get all data from this article, Assay Method | ||
Histone-lysine N-methyltransferase EZH2 [A687V] | |||
Name: | Histone-lysine N-methyltransferase EZH2 [A687V] | ||
Synonyms: | EZH2 | EZH2_HUMAN | Histone-lysine N-methyltransferase EZH2 (A687V) | KMT6 | ||
Type: | Protein | ||
Mol. Mass.: | 85395.90 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q15910[A687V] | ||
Residue: | 746 | ||
Sequence: |
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BDBM190221 | |||
n/a | |||
Name | BDBM190221 | ||
Synonyms: | EPZ009156 | US9175331, 58 | ||
Type | Small organic molecule | ||
Emp. Form. | C29H39ClN4O3 | ||
Mol. Mass. | 527.098 | ||
SMILES | CCN([C@H]1CC[C@@H](CC1)C(=O)N1CCCC1)c1cc(Cl)cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r,wU:3.2,wD:6.9,(-2.67,-3.05,;-1.33,-3.82,;,-3.05,;1.33,-3.82,;2.67,-3.05,;4,-3.82,;4,-5.36,;2.67,-6.13,;1.33,-5.36,;5.33,-6.13,;6.67,-5.36,;5.33,-7.67,;4.09,-8.58,;4.56,-10.04,;6.1,-10.04,;6.58,-8.58,;,-1.51,;1.33,-.74,;1.33,.8,;2.67,1.57,;,1.57,;-1.33,.8,;-2.67,1.57,;-4,.8,;-2.67,3.11,;-4,3.88,;-4,5.42,;-5.33,6.19,;-6.67,5.42,;-5.33,7.73,;-4,8.5,;-4,10.04,;-2.67,7.73,;-2.67,6.19,;-1.33,5.42,;-1.33,-.74,;-2.67,-1.51,)| | ||
Structure |