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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Histone-lysine N-methyltransferase EZH2 [A687V] | ||
| Ligand | BDBM190222 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Inhibition Assay | ||
| IC50 | 43.6±n/a nM | ||
| Citation |  Kuntz, KW; Knutson, SK; Wigle, TJ Inhibitors of human EZH2, and methods of use thereof US Patent US9175331 Publication Date 11/3/2015 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Histone-lysine N-methyltransferase EZH2 [A687V] | |||
| Name: | Histone-lysine N-methyltransferase EZH2 [A687V] | ||
| Synonyms: | EZH2 | EZH2_HUMAN | Histone-lysine N-methyltransferase EZH2 (A687V) | KMT6 | ||
| Type: | Protein | ||
| Mol. Mass.: | 85395.90 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q15910[A687V] | ||
| Residue: | 746 | ||
| Sequence: |
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| BDBM190222 | |||
| n/a | |||
| Name | BDBM190222 | ||
| Synonyms: | EPZ009157 | US9175331, 59 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C29H39ClN4O3 | ||
| Mol. Mass. | 527.098 | ||
| SMILES | CCN([C@H]1CC[C@H](CC1)C(=O)N1CCCC1)c1cc(Cl)cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r,wU:3.2,6.9,(-2.67,-3.05,;-1.33,-3.82,;,-3.05,;1.33,-3.82,;2.67,-3.05,;4,-3.82,;4,-5.36,;2.67,-6.13,;1.33,-5.36,;5.33,-6.13,;6.67,-5.36,;5.33,-7.67,;4.09,-8.58,;4.56,-10.04,;6.1,-10.04,;6.58,-8.58,;,-1.51,;1.33,-.74,;1.33,.8,;2.67,1.57,;,1.57,;-1.33,.8,;-2.67,1.57,;-4,.8,;-2.67,3.11,;-4,3.88,;-4,5.42,;-5.33,6.19,;-6.67,5.42,;-5.33,7.73,;-4,8.5,;-4,10.04,;-2.67,7.73,;-2.67,6.19,;-1.33,5.42,;-1.33,-.74,;-2.67,-1.51,)| | ||
| Structure | 
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