| Reaction Details |
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 | Report a problem with these data |
| Target | Arachidonate 15-lipoxygenase |
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| Ligand | BDBM32020 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | LoxA Selectivity Assay |
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| pH | 7±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 5e+2±n/a nM |
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| Comments | extracted |
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| Citation |  Deschamps, JD; Ogunsola, AF; Jameson, JB; Yasgar, A; Flitter, BA; Freedman, CJ; Melvin, JA; Nguyen, JV; Maloney, DJ; Jadhav, A; Simeonov, A; Bomberger, JM; Holman, TR Biochemical and Cellular Characterization and Inhibitor Discovery of Pseudomonas aeruginosa 15-Lipoxygenase. Biochemistry55:3329-40 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Arachidonate 15-lipoxygenase |
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| Name: | Arachidonate 15-lipoxygenase |
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| Synonyms: | 15-Lipoxygenase (LoxA) |
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| Type: | Protein |
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| Mol. Mass.: | 74804.41 |
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| Organism: | Pseudomonas aeruginosa |
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| Description: | n/a |
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| Residue: | 685 |
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| Sequence: | MKRRSVLLSGVALSGTALANDSIFFSPLKYLGAEQQRSIDASRSLLDNLIPPSLPQYDNL
AGKLARRAVLTSKKLVYVWTENFGNVKGVPMARSVPLGELPNVDWLLKTAGVIVELIVNF
VASLPASAAAQFERIATGLSGDLEAARQVHEALLEEAKNDPAAAGSLLLRFTELQTRVIA
ILTRVGLLVDDILKSASNLVTQRGQGDGLNRFRAVFGTLRLPEVADSFRDDEAFAYWRVA
GPNPLLIRRVDALPANFPLGEEQFRRVMGADDSLLEAAASRRLYLLDYAELGKLAPSGAV
DKLLTGTGFAYAPIALFALGKDRARLLPVAIQCGQDPATHPMFVRPAESESDLYWGWQMA
KTVVQVAEENYHEMFVHLAQTHLVSEAFCLATQRTLAPSHPLHVLLAPHFEGTLFINEGA
ARILLPSAGFIDVMFAAPIQDTQATAGGNRLGFDFYRGMLPESLKARNVDDPLALPDYPY
RDDGLLVWNAIRQWAADYVAVYYASDGDVTADVELAAWVGEVIGSGKVAGFRPITGRSQL
VEVLTMVIFTASAQHAAVNFPQPSMMTYAPAICAMSAAPAPDSPSGKSEADWLKMMPPTL
VALEKVNIYHLLGSVYHGRLGDYRQTGFPYAPVFSDRRVTASGGPLERFQARLKEVEATI
RTRNQARRRPYEYLLPSRIPASTNI
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| BDBM32020 |
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| n/a |
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| Name | BDBM32020 |
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| Synonyms: | 4-[4-(3,4-dihydroxyphenyl)-2,3-dimethyl-butyl]pyrocatechol | 4-[4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol | 4-[4-[3,4-bis(oxidanyl)phenyl]-2,3-dimethyl-butyl]benzene-1,2-diol | BDBM166684 | CHEMBL52 | LOX inhibitor, N/A | MLS000069451 | NORDIHYDROGUAIARETIC ACID | Nordihydroguaiaretic acid (NDGA) | SMR000059049 | US10857082, Compound 2.18 | cid_4534 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H22O4 |
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| Mol. Mass. | 302.3649 |
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| SMILES | CC(Cc1ccc(O)c(O)c1)C(C)Cc1ccc(O)c(O)c1 |
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| Structure | 
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