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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Beta-secretase 2 | ||
| Ligand | BDBM190808 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | HTRF FRET Assay | ||
| pH | 5±n/a | ||
| Temperature | 303.15±n/a K | ||
| Ki | 1.7±n/a nM | ||
| Comments | extracted | ||
| Citation |  Wu, W; Burnett, DA; Stamford, AW; Cumming, JN; Asberom, T; Bennett, C; Sasiskumar, TK; Scott, JD 2-spiro-substituted iminothiazines and their mono-and dioxides as bace inhibitors, compositions and their use US Patent US9181236 Publication Date 11/10/2015 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Beta-secretase 2 | |||
| Name: | Beta-secretase 2 | ||
| Synonyms: | AEPLC | ALP56 | ASP1 | ASP21 | Asp 1 | Aspartic-like protease 56 kDa | Aspartyl protease 1 | BACE2 | BACE2_HUMAN | Beta secretase 2 | Beta-secretase (BACE) | Beta-secretase 2 | Beta-secretase 2 (BACE-2) | Beta-secretase 2 precursor | Beta-site APP-cleaving enzyme 2 | Down region aspartic protease | Memapsin-1 | Membrane-associated aspartic protease 1 | beta-Secretase (BACE-2) | ||
| Type: | Protein | ||
| Mol. Mass.: | 56171.20 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q9Y5Z0 | ||
| Residue: | 518 | ||
| Sequence: |
| ||
| BDBM190808 | |||
| n/a | |||
| Name | BDBM190808 | ||
| Synonyms: | US9181236, 75 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H20F2N4O4S | ||
| Mol. Mass. | 450.459 | ||
| SMILES | C[C@]1(CS(=O)(=O)[C@]2(C[C@H](O)C2)C(=N)N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F |r,wU:6.10,8.8,1.0,(1.86,-4.05,;.68,-3.06,;-.09,-4.39,;-1.63,-4.39,;-1.68,-5.93,;-2.93,-5.21,;-2.4,-3.06,;-3.49,-1.97,;-4.57,-3.06,;-6.11,-3.06,;-3.49,-4.15,;-1.63,-1.73,;-2.4,-.39,;-.09,-1.73,;1.86,-2.07,;1.6,-.55,;2.78,.44,;2.51,1.95,;3.69,2.94,;5.13,2.42,;3.42,4.46,;4.6,5.45,;4.33,6.97,;2.89,7.49,;2.62,9.01,;1.71,6.5,;1.97,4.99,;4.22,-.09,;4.49,-1.61,;3.31,-2.6,;3.58,-4.11,)| | ||
| Structure | 
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