| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 family 11 subfamily B member 2 |
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| Ligand | BDBM191287 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Aldosterone Synthase Inhibition Assay |
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| pH | 7.4±n/a |
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| IC50 | 5.2±n/a nM |
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| Comments | extracted |
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| Citation |  Balestra, M; Burke, J; Chen, Z; Cogan, D; Fader, L; Guo, X; McKibben, B; Marshall, DR; Nemoto, PA; Yu, H Aldosterone synthase inhibitors US Patent US9181272 Publication Date 11/10/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 family 11 subfamily B member 2 |
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| Name: | Cytochrome P450 family 11 subfamily B member 2 |
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| Synonyms: | Aldosterone Synthase (CYP11B2) |
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| Type: | n/a |
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| Mol. Mass.: | 51334.55 |
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| Organism: | Cercopithecus sabaeus |
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| Description: | Aldeosterone synthase (CYP11B2) from frozen cynomolgus monkey adrenal gland |
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| Residue: | 451 |
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| Sequence: | MALRAKAEVCMAAPWLSLQRAQALSTRAARAPSTVLPFEAIPQRPGSRWLRLLQIWREQG
YEHLHLEVHQTFQELGPIFRNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQAL
RNKVVQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLSFLHALEVMFK
STVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELALSRPQQYTGIVAE
LLLNAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQALRQESLAAAASIS
EHPQKATTELPLMRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGR
NPALFPRPERYNPQRWLDIRGSGKNFHNVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQ
VETLTQEDIKMVYSFILRPSTFPLLTFRAIN
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| BDBM191287 |
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| n/a |
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| Name | BDBM191287 |
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| Synonyms: | US9181272, 57 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H21N5O2 |
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| Mol. Mass. | 387.4344 |
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| SMILES | CNC(=O)c1ccc(cc1)-c1cncc(c1)-c1cnc2N(CCCc2c1)C(N)=O |
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| Structure | 
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