| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cytochrome P450 family 11 subfamily B member 2 |
|---|
| Ligand | BDBM191346 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Aldosterone Synthase Inhibition Assay |
|---|
| pH | 7.4±n/a |
|---|
| IC50 | 3.5±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Balestra, M; Burke, J; Chen, Z; Cogan, D; Fader, L; Guo, X; McKibben, B; Marshall, DR; Nemoto, PA; Yu, H Aldosterone synthase inhibitors US Patent US9181272 Publication Date 11/10/2015 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cytochrome P450 family 11 subfamily B member 2 |
|---|
| Name: | Cytochrome P450 family 11 subfamily B member 2 |
|---|
| Synonyms: | Aldosterone Synthase (CYP11B2) |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | 51334.55 |
|---|
| Organism: | Cercopithecus sabaeus |
|---|
| Description: | Aldeosterone synthase (CYP11B2) from frozen cynomolgus monkey adrenal gland |
|---|
| Residue: | 451 |
|---|
| Sequence: | MALRAKAEVCMAAPWLSLQRAQALSTRAARAPSTVLPFEAIPQRPGSRWLRLLQIWREQG
YEHLHLEVHQTFQELGPIFRNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQAL
RNKVVQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLSFLHALEVMFK
STVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELALSRPQQYTGIVAE
LLLNAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQALRQESLAAAASIS
EHPQKATTELPLMRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGR
NPALFPRPERYNPQRWLDIRGSGKNFHNVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQ
VETLTQEDIKMVYSFILRPSTFPLLTFRAIN
|
|
|
|---|
| BDBM191346 |
|---|
| n/a |
|---|
| Name | BDBM191346 |
|---|
| Synonyms: | US9181272, 116 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H21N5O |
|---|
| Mol. Mass. | 359.4243 |
|---|
| SMILES | NC(=O)N1CCCc2cc(cnc12)-c1cncc(NCc2ccccc2)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
