Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Epidermal growth factor receptor | ||
| Ligand | BDBM97672 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | HotSpot kinase assay | ||
| IC50 | 20.6±n/a nM | ||
| Citation |  Honigberg, L; Verner, E; Buggy, JJ; Loury, D; Chen, W Inhibitors of bruton's tyrosine kinase US Patent US9181263 Publication Date 11/10/2015 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Epidermal growth factor receptor | |||
| Name: | Epidermal growth factor receptor | ||
| Synonyms: | EGF Receptor Substrate | EGFR | EGFR_HUMAN | ERBB | ERBB1 | Epidermal Growth Factor Receptor Tyrosine Kinase | Epidermal Growth Factor Receptor erbB-1 | Epidermal Growth Factor Receptor, ErbB-1 | Epidermal growth factor receptor (EGFR) | Epidermal growth factor receptor (HER1) | HER1 | Protein-Tyrosine Kinase Erbb-1 | Proto-oncogene c-ErbB-1 | Receptor tyrosine-protein kinase ErbB-1 | Tyrosine-Protein Kinase ErbB-1 | ||
| Type: | Receptor Kinase Domain | ||
| Mol. Mass.: | 134279.59 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P00533 | ||
| Residue: | 1210 | ||
| Sequence: |
| ||
| BDBM97672 | |||
| n/a | |||
| Name | BDBM97672 | ||
| Synonyms: | US8476284, 40 | US9133201, 10 | US9181263, 9 | US9278100, 9 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H26N6O2 | ||
| Mol. Mass. | 454.5236 | ||
| SMILES | Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)[C@@H]1CC[C@@H](CC1)NC(=O)C=C |r,wU:23.26,26.33,(-3.76,2.88,;-3.76,1.34,;-5.09,.57,;-5.09,-.97,;-3.76,-1.74,;-2.43,-.97,;-.96,-1.45,;-.06,-.2,;-.96,1.05,;-.56,2.53,;.92,2.93,;1.32,4.42,;.23,5.51,;.63,7,;2.12,7.4,;3.21,6.31,;4.7,6.7,;5.09,8.19,;4.01,9.28,;2.52,8.88,;-1.25,5.11,;-1.65,3.62,;-2.43,.57,;-.56,-2.93,;-1.65,-4.02,;-1.25,-5.51,;.23,-5.91,;1.32,-4.82,;.92,-3.33,;.63,-7.4,;2.12,-7.79,;2.52,-9.28,;3.21,-6.7,;4.7,-7.1,)| | ||
| Structure | 
| ||