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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase Lck | ||
| Ligand | BDBM191622 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | HotSpot kinase assay | ||
| IC50 | 0.76±n/a nM | ||
| Citation |  Honigberg, L; Verner, E; Buggy, JJ; Loury, D; Chen, W Inhibitors of bruton's tyrosine kinase US Patent US9181263 Publication Date 11/10/2015 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase Lck | |||
| Name: | Tyrosine-protein kinase Lck | ||
| Synonyms: | 2.7.10.2 | LCK | LCK_HUMAN | LSK | Leukocyte C-terminal Src kinase | Lymphocyte cell-specific protein-tyrosine kinase | Lymphocyte-specific protein tyrosine kinase | P56-LCK | Protein YT16 | Proto-oncogene Lck | Proto-oncogene tyrosine-protein kinase LCK | Src/Lck kinase | T cell-specific protein-tyrosine kinase | ||
| Type: | n/a | ||
| Mol. Mass.: | 57987.83 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P06239 | ||
| Residue: | 509 | ||
| Sequence: |
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| BDBM191622 | |||
| n/a | |||
| Name | BDBM191622 | ||
| Synonyms: | US9181263, 18 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C29H33N7O2 | ||
| Mol. Mass. | 511.618 | ||
| SMILES | CN(C)C\C=C\C(=O)N[C@H]1CC[C@@H](CC1)n1nc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc12 |r,wU:12.15,wD:9.8,(5.67,1.62,;4.9,.28,;5.67,-1.05,;3.36,.28,;2.59,-1.05,;1.05,-1.05,;.28,-2.39,;1.05,-3.72,;-1.26,-2.39,;-2.03,-1.05,;-1.26,.28,;-2.03,1.62,;-3.57,1.62,;-4.34,.28,;-3.57,-1.05,;-4.34,2.95,;-3.79,4.39,;-4.98,5.36,;-4.98,6.9,;-3.65,7.67,;-3.65,9.21,;-4.98,9.98,;-4.98,11.52,;-3.65,12.29,;-2.32,11.52,;-.98,12.29,;-.98,13.83,;-2.32,14.6,;-3.65,13.83,;-6.32,9.21,;-6.32,7.67,;-6.27,4.52,;-7.76,4.92,;-8.16,6.4,;-8.85,3.83,;-8.45,2.34,;-6.97,1.94,;-5.88,3.03,)| | ||
| Structure | 
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