| Reaction Details |
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 | Report a problem with these data |
| Target | Nuclear factor NF-kappa-B p105 subunit |
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| Ligand | BDBM191744 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Cellular Firefly Luciferase Assay (NFkB) |
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| IC50 | 3400±200 nM |
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| Citation |  Vander Jagt, DL; Deck, LM; Abcouwer, SF; Orlando, RA; Royer, RE; Weber, WM; Bobrovnikova-Marjon, EV; Hunsaker, LA Therapeutic curcumin derivatives US Patent US9187397 Publication Date 11/17/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| Nuclear factor NF-kappa-B p105 subunit |
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| Name: | Nuclear factor NF-kappa-B p105 subunit |
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| Synonyms: | NFKB1 | NFKB1_HUMAN | Nuclear factor NF-kappa-B (NF-kB) | Nuclear factor NF-kappa-B complex | Nuclear factor NF-kappa-B p105 subunit |
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| Type: | Protein |
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| Mol. Mass.: | 105329.57 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P19838 |
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| Residue: | 968 |
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| Sequence: | MAEDDPYLGRPEQMFHLDPSLTHTIFNPEVFQPQMALPTDGPYLQILEQPKQRGFRFRYV
CEGPSHGGLPGASSEKNKKSYPQVKICNYVGPAKVIVQLVTNGKNIHLHAHSLVGKHCED
GICTVTAGPKDMVVGFANLGILHVTKKKVFETLEARMTEACIRGYNPGLLVHPDLAYLQA
EGGGDRQLGDREKELIRQAALQQTKEMDLSVVRLMFTAFLPDSTGSFTRRLEPVVSDAIY
DSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQKDDIQIRFYEEEENGGVWEGFGDF
SPTDVHRQFAIVFKTPKYKDINITKPASVFVQLRRKSDLETSEPKPFLYYPEIKDKEEVQ
RKRQKLMPNFSDSFGGGSGAGAGGGGMFGSGGGGGGTGSTGPGYSFPHYGFPTYGGITFH
PGTTKSNAGMKHGTMDTESKKDPEGCDKSDDKNTVNLFGKVIETTEQDQEPSEATVGNGE
VTLTYATGTKEESAGVQDNLFLEKAMQLAKRHANALFDYAVTGDVKMLLAVQRHLTAVQD
ENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVED
LLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMM
SNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGT
TPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWENAGEDEGVVPGTTPLDMAT
SWQVFDILNGKPYEPEFTSDDLLAQGDMKQLAEDVKLQLYKLLEIPDPDKNWATLAQKLG
LGILNNAFRLSPAPSKTLMDNYEVSGGTVRELVEALRQMGYTEAIEVIQAASSPVKTTSQ
AHSLPLSPASTRQQIDELRDSDSVCDSGVETSFRKLSFTESLTSGASLLTLNKMPHDYGQ
EGPLEGKI
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| BDBM191744 |
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| n/a |
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| Name | BDBM191744 |
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| Synonyms: | US9187397, 3 | US9187397, 31 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H12N2O |
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| Mol. Mass. | 236.2686 |
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| SMILES | O=C(\C=C\c1cccnc1)/C=C/c1cccnc1 |
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| Structure | 
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