Reaction Details |
| Report a problem with these data |
Target | Nuclear factor NF-kappa-B p105 subunit |
---|
Ligand | BDBM50067033 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Cellular Firefly Luciferase Assay (NFkB) |
---|
IC50 | 4400±800 nM |
---|
Citation | Vander Jagt, DL; Deck, LM; Abcouwer, SF; Orlando, RA; Royer, RE; Weber, WM; Bobrovnikova-Marjon, EV; Hunsaker, LA Therapeutic curcumin derivatives US Patent US9187397 Publication Date 11/17/2015 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Nuclear factor NF-kappa-B p105 subunit |
---|
Name: | Nuclear factor NF-kappa-B p105 subunit |
Synonyms: | NFKB1 | NFKB1_HUMAN | Nuclear factor NF-kappa-B (NF-kB) | Nuclear factor NF-kappa-B complex | Nuclear factor NF-kappa-B p105 subunit |
Type: | Protein |
Mol. Mass.: | 105329.57 |
Organism: | Homo sapiens (Human) |
Description: | P19838 |
Residue: | 968 |
Sequence: | MAEDDPYLGRPEQMFHLDPSLTHTIFNPEVFQPQMALPTDGPYLQILEQPKQRGFRFRYV
CEGPSHGGLPGASSEKNKKSYPQVKICNYVGPAKVIVQLVTNGKNIHLHAHSLVGKHCED
GICTVTAGPKDMVVGFANLGILHVTKKKVFETLEARMTEACIRGYNPGLLVHPDLAYLQA
EGGGDRQLGDREKELIRQAALQQTKEMDLSVVRLMFTAFLPDSTGSFTRRLEPVVSDAIY
DSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQKDDIQIRFYEEEENGGVWEGFGDF
SPTDVHRQFAIVFKTPKYKDINITKPASVFVQLRRKSDLETSEPKPFLYYPEIKDKEEVQ
RKRQKLMPNFSDSFGGGSGAGAGGGGMFGSGGGGGGTGSTGPGYSFPHYGFPTYGGITFH
PGTTKSNAGMKHGTMDTESKKDPEGCDKSDDKNTVNLFGKVIETTEQDQEPSEATVGNGE
VTLTYATGTKEESAGVQDNLFLEKAMQLAKRHANALFDYAVTGDVKMLLAVQRHLTAVQD
ENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVED
LLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMM
SNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGT
TPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWENAGEDEGVVPGTTPLDMAT
SWQVFDILNGKPYEPEFTSDDLLAQGDMKQLAEDVKLQLYKLLEIPDPDKNWATLAQKLG
LGILNNAFRLSPAPSKTLMDNYEVSGGTVRELVEALRQMGYTEAIEVIQAASSPVKTTSQ
AHSLPLSPASTRQQIDELRDSDSVCDSGVETSFRKLSFTESLTSGASLLTLNKMPHDYGQ
EGPLEGKI
|
|
|
BDBM50067033 |
---|
n/a |
---|
Name | BDBM50067033 |
Synonyms: | (2E,6E)-2,6-bis(4-hydroxy-3-methoxybenzylidene)cyclohexanone | 2,6-Bis((3-methoxy-4-hydroxyphenyl)methylene)-cyclohexanone | 2,6-Bis-(4-hydroxy-3-methoxy-benzylidene)-cyclohexanone | 2,6-Bis-[1-(4-hydroxy-3-methoxy-phenyl)-meth-(E)-ylidene]-cyclohexanone | 2,6-bis(4-hydroxy-3-methoxybenzylidene)cyclohexanone | CHEMBL17205 | Cyclovalone | US9187397, 38a | cid_1550234 |
Type | Small organic molecule |
Emp. Form. | C22H22O5 |
Mol. Mass. | 366.4071 |
SMILES | COc1cc(\C=C2/CCC\C(=C/c3ccc(O)c(OC)c3)C2=O)ccc1O |
Structure |
|