| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome b |
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| Ligand | BDBM192084 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Cytochrome b Enzyme Assay |
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| pH | 7.4±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 1142±n/a nM |
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| Comments | extracted |
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| Citation |  Vincent, BM; Langlois, JB; Srinivas, R; Lancaster, AK; Scherz-Shouval, R; Whitesell, L; Tidor, B; Buchwald, SL; Lindquist, S A Fungal-Selective Cytochrome bc1 Inhibitor Impairs Virulence and Prevents the Evolution of Drug Resistance. Cell Chem Biol23:978-991 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome b |
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| Name: | Cytochrome b |
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| Synonyms: | n/a |
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| Type: | Protein |
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| Mol. Mass.: | 43717.83 |
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| Organism: | Candida albicans (Yeast) |
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| Description: | n/a |
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| Residue: | 387 |
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| Sequence: | MPTRKSNTYLSLVNSYLIDSPQPSSINYWWNLGSLLGLCLVIQIASGVFLAMHYSSNIEL
AFDSVEHIMRDVNAGWLIRYIHANGASFFFICMYLHIGKALYYGSYKQPRVMLWVIGVVI
FILTMAIAFMGYCLVYGQMSHWGATVITNLLSAIPFIGNDIVPFIWGGFSVSNPTIQRFF
ALHFLLPFILAALVCMHLMALHVHGSSNPVGITGNIDRLPMHPYFIFKDLITVFVFLLIF
SLFVFYSPNTLGHPDNYIPGNPMVTPPSIVPEWYLLPFYAILRSIPDKLGGVIAMFGAIL
ILLSLPYTDRSIIRGNSFKVLSKLAFYLFVFNFILLGNLGQLHVEVPYIQLGQFATAYYF
AHYIIVVPVISTLENILYYIGTQTRVK
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| BDBM192084 |
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| n/a |
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| Name | BDBM192084 |
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| Synonyms: | Inz-75 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H32N2O3 |
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| Mol. Mass. | 444.5653 |
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| SMILES | COC(=O)Cn1nc(-c2cccc(OCCC34CC5CC(CC(C5)C3)C4)c2)c2ccccc12 |TLB:19:20:24:18.23.17,23:18:25:22.24.21,23:22:25:19.18.17,THB:19:18:24:25.20.21| |
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| Structure | 
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