| Reaction Details |
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 | Report a problem with these data |
| Target | Lipoxygenase |
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| Ligand | BDBM192701 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In-vitro LOX Inhibition Assay |
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| pH | 9±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 3.239±0.575 nM |
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| Comments | extracted |
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| Citation |  Srivastava, P; Vyas, VK; Variya, B; Patel, P; Qureshi, G; Ghate, M Synthesis, anti-inflammatory, analgesic, 5-lipoxygenase (5-LOX) inhibition activities, and molecular docking study of 7-substituted coumarin derivatives. Bioorg Chem67:130-8 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lipoxygenase |
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| Name: | Lipoxygenase |
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| Synonyms: | 5-Lipoxygenase (5-LOX) |
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| Type: | Protein |
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| Mol. Mass.: | 97266.07 |
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| Organism: | Glycine max (Soybean) |
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| Description: | n/a |
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| Residue: | 866 |
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| Sequence: | MFSVPGVSGILNRGGGHKIKGTVVLMRKNVLDFNSVADLTKGNVGGLIGTGLNVVGSTLD
NLTAFLGRSVALQLISATKPLANGKGKVGKDTFLEGIIVSLPTLGAGESAFNIQFEWDES
MGIPGAFYIKNYMQVEFYLKSLTLEDVPNQGTIRFVCNSWVYNTKLYKSVRIFFANHTYV
PSETPAALVGYREEELKNLRGDGKGERKEHDRIYDYDVYNDLGNPDHGENFARPILGGSS
THPYPRRGRTGRYPTRKDQNSEKPGEVYVPRDENFGHLKSSDFLAYGIKSLSQYVLPAFE
SVFDLNFTPNEFDSFQDVRDLHEGGIKLPTEVISTIMPLPVVKELFRTDGEQVLKFPPPH
VIQVSKSAWMTDEEFAREMVAGVNPCVIRGLQEFPPKSNLDPTIYGEQTSKITADALDLD
GYTVDEALASRRLFMLDYHDVFMPYIRRINQTYAKAYATRTILFLRENGTLKPVAIELSL
PHPAGDLSGAVSQVILPAKEGVESTIWLLAKAYVVVNDSCYHQLMSHWLNTQAVIEPFII
ATNRHLSALHPIYKLLTPHYRDTMNINALARQSLINADGIIEKSFLPSKHSVEMSSAVYK
NWVFTDQALPADLIKRGVAIKDPSAPHGLRLLIEDYPYAVDGLEIWAAIKTWVQEYVSLY
YARDDDVKPDSELQQWWKEAVEKGHGDLKDKPWWPKLQTIEELVEICTIIIWTASALHAA
VNFGQYPYGGFILNRPTSSRRLLPEKGTPEYEEMVKSHQKAYLRTITSKFQTLVDLSVIE
ILSRHASDEVYLGQRDNPHWTSDSKALQAFQKFGNKLKEIEEKLARKNNDQSLSNRLGPV
QLPYTLLHPNSEEGLTCRGIPNSISI
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| BDBM192701 |
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| n/a |
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| Name | BDBM192701 |
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| Synonyms: | 7-(2-hydroxy-3-(6-nitrobenzo[d]thiazol-2-ylamino)propoxy)-4-methyl-2H-chromen-2-one (31) |
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| Type | Small organic molecule |
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| Emp. Form. | C20H17N3O6S |
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| Mol. Mass. | 427.43 |
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| SMILES | Cc1cc(=O)oc2cc(OCC(O)CNc3nc4ccc(cc4s3)[N+]([O-])=O)ccc12 |
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| Structure | 
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