Reaction Details |
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Target | Serine/threonine-protein kinase/endoribonuclease IRE1 [547-977] |
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Ligand | BDBM192730 |
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Substrate/Competitor | n/a |
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Meas. Tech. | In vitro RNase Assay |
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IC50 | 1.9e+2± 1e+1 nM |
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Citation | Feldman, HC; Tong, M; Wang, L; Meza-Acevedo, R; Gobillot, TA; Lebedev, I; Gliedt, MJ; Hari, SB; Mitra, AK; Backes, BJ; Papa, FR; Seeliger, MA; Maly, DJ Structural and Functional Analysis of the Allosteric Inhibition of IRE1a with ATP-Competitive Ligands. ACS Chem Biol11:2195-205 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Serine/threonine-protein kinase/endoribonuclease IRE1 [547-977] |
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Name: | Serine/threonine-protein kinase/endoribonuclease IRE1 [547-977] |
Synonyms: | ERN1 | ERN1_HUMAN | IRE1 | IRE1α |
Type: | Protein |
Mol. Mass.: | 49232.75 |
Organism: | Homo sapiens (Human) |
Description: | Cytosolic kinase and RNase domains of human IRE1α (residues 547-977) in SF9 insect cells |
Residue: | 431 |
Sequence: | GSSPSLEQDDGDEETSVVIVGKISFCPKDVLGHGAEGTIVYRGMFDNRDVAVKRILPECF
SFADREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPI
TLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFS
RRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANIL
LGACSLDCLHPEKHEDVIARELIEKMIAMDPQKRPSAKHVLKHPFFWSLEKQLQFFQDVS
DRIEKESLDGPIVKQLERGGRAVVKMDWRENITVPLQTDLRKFRTYKGGSVRDLLRAMRN
KKHHYRELPAEVRETLGSLPDDFVCYFTSRFPHLLAHTYRAMELCSHERLFQPYYFHEPP
EPQPPVTPDAL
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BDBM192730 |
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n/a |
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Name | BDBM192730 |
Synonyms: | KIRA analog, 12 |
Type | Small organic molecule |
Emp. Form. | C27H24N6O |
Mol. Mass. | 448.5191 |
SMILES | CC1(CC1)c1nc(-c2ccc(NC(=O)Nc3ccccc3)c3ccccc23)c2c(N)nccn12 |
Structure |
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