| Reaction Details |
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 | Report a problem with these data |
| Target | Presenilin-1 |
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| Ligand | BDBM193017 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Cell-Based Assay |
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| Temperature | 310.15±n/a K |
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| IC50 | 140±n/a nM |
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| Comments | extracted |
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| Citation |  Pettersson, MY; Johnson, DS; Subramanyam, C; O'Donnell, CJ; am Ende, CW; Green, ME; Patel, NC; Stiff, CM; Tran, TP; Kauffman, GW; Stepan, AF; Verhoest, PR Substituted pyrido[1,2-a]pyrazines for the treatment of neurodegenerative and neurological disorders US Patent US9193726 Publication Date 11/24/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| Presenilin-1 |
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| Name: | Presenilin-1 |
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| Synonyms: | 3.4.23.- | AD3 | Gamma-Secretase Subunit Presenilin-1 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSN1_HUMAN | PSNL1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Protein S182 |
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| Type: | n/a |
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| Mol. Mass.: | 52657.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49768 |
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| Residue: | 467 |
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| Sequence: | MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSR
QVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTE
DTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFI
YLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKY
LPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAE
GDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAA
VQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCL
TLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
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| BDBM193017 |
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| n/a |
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| Name | BDBM193017 |
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| Synonyms: | US9193726, 5 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H22F4N4O3 |
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| Mol. Mass. | 490.4501 |
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| SMILES | Cc1cn(cn1)-c1ccc2C(=O)N(CCn2c1=O)[C@@H]1CCC[C@@H]1Oc1ccc(F)cc1C(F)(F)F |
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| Structure | 
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