Reaction Details | |||
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Target | Presenilin-1 | ||
Ligand | BDBM193034 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Cell-Based Assay | ||
Temperature | 310.15±n/a K | ||
IC50 | 789±n/a nM | ||
Comments | extracted | ||
Citation | Pettersson, MY; Johnson, DS; Subramanyam, C; O'Donnell, CJ; am Ende, CW; Green, ME; Patel, NC; Stiff, CM; Tran, TP; Kauffman, GW; Stepan, AF; Verhoest, PR Substituted pyrido[1,2-a]pyrazines for the treatment of neurodegenerative and neurological disorders US Patent US9193726 Publication Date 11/24/2015 | ||
More Info.: | Get all data from this article, Assay Method | ||
Presenilin-1 | |||
Name: | Presenilin-1 | ||
Synonyms: | 3.4.23.- | AD3 | Gamma-Secretase Subunit Presenilin-1 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSN1_HUMAN | PSNL1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Protein S182 | ||
Type: | n/a | ||
Mol. Mass.: | 52657.13 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P49768 | ||
Residue: | 467 | ||
Sequence: |
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BDBM193034 | |||
n/a | |||
Name | BDBM193034 | ||
Synonyms: | US9193726, 22 | ||
Type | Small organic molecule | ||
Emp. Form. | C23H21F3N4O3 | ||
Mol. Mass. | 458.433 | ||
SMILES | Cc1cn(cn1)-c1ccc2C(=O)N(CCn2c1=O)[C@H]1C[C@@H](C1)Oc1ccccc1C(F)(F)F |wU:18.20,wD:20.25,(11.86,-6.76,;11.24,-5.36,;9.73,-5.04,;9.57,-3.5,;10.98,-2.88,;12.01,-4.02,;8.24,-2.73,;8.24,-1.19,;6.9,-.42,;5.57,-1.19,;4.24,-.42,;4.24,1.12,;2.9,-1.19,;2.9,-2.73,;4.24,-3.5,;5.57,-2.73,;6.9,-3.5,;6.9,-5.04,;1.57,-.42,;.08,-.82,;-.32,.66,;1.17,1.06,;-1.65,1.43,;-1.65,2.97,;-.32,3.74,;-.32,5.28,;-1.65,6.05,;-2.98,5.28,;-2.98,3.74,;-4.32,2.97,;-5.65,2.2,;-5.09,4.31,;-3.55,1.64,)| | ||
Structure |