| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Beta-glucuronidase |
|---|
| Ligand | BDBM152586 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | β-Glucuronidase assay |
|---|
| IC50 | 4.84e+4± 1.25e+3 nM |
|---|
| Citation |  Taha, M; Ismail, NH; Imran, S; Wadood, A; Rahim, F; Al Muqarrabin, LM; Zaki, HM; Ahmat, N; Nasir, A; Khan, F Synthesis of novel disulfide and sulfone hybrid scaffolds as potent ß-glucuronidase inhibitor. Bioorg Chem68:15-22 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Beta-glucuronidase |
|---|
| Name: | Beta-glucuronidase |
|---|
| Synonyms: | Beta-glucuronidase | Beta-glucuronidase (β-glucuronidase) | EMBL:AAI33416.1 | Ensembl:ENSBTAP00000000941 | Ensembl:ENSBTAP00000000941} | GUSB |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 74467.69 |
|---|
| Organism: | Bos taurus (Bovine) |
|---|
| Description: | EC 3.2.1.31, bovine liver |
|---|
| Residue: | 652 |
|---|
| Sequence: | MLRGSAGAWAVLGPLLWGCGLSLLQGGMLYPRESRSRERKELDGLWSFRADFSDNRRQGF
EQQWYRAPLRESGPTLDMPVPSSFNDVGQDGQLRSFVGWVWYEREITLPQRWTEDLGTRV
VLRIGSAHYYAIVWVNGVHVLEHEGGHLPFEADISKLVQSGPLSSCRITIAINNTLSPHT
LPPGTILYKTDPSMYPKGYFVQNTKFDFFNYAGLHRSVLLYTTPTTYIDDITVTTDMDQD
IGLVNYQIIVQGSDHFQVDVSLLDEEGKVMAKGAGAEGQLQVPSAHLWWPYLMHEHPAYL
YSLEVKLTAQTAVGPVSDFYTLPVGIRTVAVTKSQFLINGKPFYFRGVNKHEDADIRGKG
FDWPLLVKDFNLLRWLGANAFRTSHYPYSEEVLQLCDRYGIVVIDESPGVGIVLVESFSN
VSLQHHLEVMEEMIRRDKNHPAVVMWSLANEPASFLKPAGYYFKTLIAHTKALDPSRPVT
FVTNTNYEADLGAPYVDIICVNSYYSWYHDYGHMEVIQLQLATQFENWYKAYQKPMIQSE
YGADAIEGFHEDPPLMFSEEYQKGLLQQYHVVLDQKRKEYVVGELIWNFADFMTNQSPVR
MIGNRKGIFTRQRQPKSAAFLLRERYWKLANETRYQRSAVTSQCVGSGLFTV
|
|
|
|---|
| BDBM152586 |
|---|
| n/a |
|---|
| Name | BDBM152586 |
|---|
| Synonyms: | D-Saccharic acid 1,4 lactone | D-Saccharic acid 1,4-lactone | D-Saccharic acid 1,4-lactone | D-saccharic acid-1,4-lactone |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C6H8O7 |
|---|
| Mol. Mass. | 192.1235 |
|---|
| SMILES | OC(C1OC(=O)C(O)C1O)C(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
