Reaction Details |
| Report a problem with these data |
Target | Hematopoietic prostaglandin D synthase |
---|
Ligand | BDBM193897 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Biochemical Assay |
---|
pH | 8±n/a |
---|
IC50 | 660±1100 nM |
---|
Comments | extracted |
---|
Citation | Smythe, ML; Flanagan, JU Haematopoietic-prostaglandin D2 synthase inhibitors US Patent US9199976 Publication Date 12/1/2015 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Hematopoietic prostaglandin D synthase |
---|
Name: | Hematopoietic prostaglandin D synthase |
Synonyms: | GSTS | Glutathione-dependent PGD synthetase | Glutathione-requiring prostaglandin D synthase | H-PGDS | HPGDS | HPGDS_HUMAN | Hematopoietic prostaglandin D synthase | Hematopoietic prostaglandin D synthase (H-PGDS) | Hematopoietic prostaglandin D synthase (HPGDS) | PGDS | PTGDS2 | Prostaglandin D | Prostaglandin D Synthase |
Type: | Enzyme |
Mol. Mass.: | 23341.07 |
Organism: | Homo sapiens (Human) |
Description: | The protein was expressed in E. coli strain BL21(DE3) with an N-terminal 6-His tag. |
Residue: | 199 |
Sequence: | MPNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPEIKSTLPFGKIPILEVDGLT
LHQSLAIARYLTKNTDLAGNTEMEQCHVDAIVDTLDDFMSCFPWAEKKQDVKEQMFNELL
TYNAPHLMQDLDTYLGGREWLIGNSVTWADFYWEICSTTLLVFKPDLLDNHPRLVTLRKK
VQAIPAVANWIKRRPQTKL
|
|
|
BDBM193897 |
---|
n/a |
---|
Name | BDBM193897 |
Synonyms: | US9199976, 9 |
Type | Small organic molecule |
Emp. Form. | C18H14N2O3S |
Mol. Mass. | 338.38 |
SMILES | OC(=O)c1ccc(CNC(=O)c2ccc(nc2)-c2cccs2)cc1 |
Structure |
|