| Reaction Details |
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 | Report a problem with these data |
| Target | Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D (hPDE4D3) |
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| Ligand | BDBM194487 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Diaxonhit Phosphodiesterase Assay |
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| pH | 7.4±n/a |
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| Temperature | 310.15±n/a K |
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| IC50 | 194±n/a nM |
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| Comments | extracted |
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| Citation |  Leblond, B; Taverne, T; Chauvignac, C; Beausoleil, E; Casagrande, A; Desire, L; Pando, MP; Donello, JE; Yang, R Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A) US Patent US9200016 Publication Date 12/1/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D (hPDE4D3) |
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| Name: | Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D (hPDE4D3) |
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| Synonyms: | DPDE3 | Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D | NP_000914.2 | PDE4C1 | PDE4D | PDE4D3 | PDE4D_HUMAN | PDE4E3 | Q08499-2 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | cAMP-specific 3',5'-cyclic phosphodiesterase 4D (hPDE4D3) |
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| Type: | n/a |
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| Mol. Mass.: | 76431.39 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q08499-2 |
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| Residue: | 673 |
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| Sequence: | MMHVNNFPFRRHSWICFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSD
SDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSP
MCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNREL
THLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSL
TNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKT
FKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAI
FASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTK
KQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMV
HCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFID
YIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQF
ELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVGEEEESQ
PEACVIDDRSPDT
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| BDBM194487 |
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| n/a |
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| Name | BDBM194487 |
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| Synonyms: | US9200016, 169 | US9902710, Compound 169 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H21F3N2O4 |
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| Mol. Mass. | 458.4297 |
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| SMILES | COCc1ncc(Cc2cnc3ccc(O)c(c3c2)C(F)(F)F)c2cc(OC)c(OC)cc12 |
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| Structure | 
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