Reaction Details |
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Target | Prostaglandin D2 receptor 2 |
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Ligand | BDBM197028 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Radioligand Binding Assay |
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pH | 7.4±n/a |
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Ki | 0.7±n/a nM |
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Comments | extracted |
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Citation | Martyres, D; Anderskewitz, R; Hoenke, C; Kriegl, J; Oost, T; Rist, W; Seither, P Pyrazole compounds as CRTH2 antagonists US Patent US9206164 Publication Date 12/8/2015 |
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More Info.: | Get all data from this article, Assay Method |
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Prostaglandin D2 receptor 2 |
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Name: | Prostaglandin D2 receptor 2 |
Synonyms: | CD_antigen=CD294 | CRTH2 | Chemoattractant Receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2) | Chemoattractant receptor-homologous molecule expressed on Th2 cells | Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) | DL1R | G protein-coupled receptor 44 | G-protein coupled receptor 44 | GPR44 | PD2R2_HUMAN | PTGDR2 | Prostaglandin D2 | Prostaglandin D2 receptor 2 | Prostaglandin D2 receptor 2 (PGD2) |
Type: | Enzyme |
Mol. Mass.: | 43295.45 |
Organism: | Homo sapiens (Human) |
Description: | Q9Y5Y4 |
Residue: | 395 |
Sequence: | MSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCR
MRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGF
LLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRI
MCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRR
PGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVAN
PVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRP
EEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS
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BDBM197028 |
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n/a |
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Name | BDBM197028 |
Synonyms: | US9206164, 92 |
Type | Small organic molecule |
Emp. Form. | C21H20FN5O3 |
Mol. Mass. | 409.4136 |
SMILES | COc1ccc2[nH]c(nc2n1)-c1ccc(Cn2nc(C)c(CC(O)=O)c2C)c(F)c1 |
Structure |
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