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TargetMetabotropic glutamate receptor 8 (mGlu8)
LigandBDBM196914
Substrate/Competitorn/a
Meas. Tech.Pharmacological Assay
EC50 21900±6300 nM
Citation Acher FPin JGoudet CEschalier ABusserolles JRigault DLemasson ICesarini SCommare B Hypophosphorous acid derivatives having antihyperalgic activity and biological applications thereof US Patent  US9212196 Publication Date 12/15/2015
More Info.:Get all data from this article,  Assay Method
 
Metabotropic glutamate receptor 8 (mGlu8)
Name:Metabotropic glutamate receptor
Synonyms:GRM8 | glutamate receptor, metabotropic 8 precursor | mGlu8 | mGluR8 | metabotropic glutamate 8
Type:Enzyme
Mol. Mass.:101886.18
Organism:Rattus norvegicus (Rat)
Description:P70579
Residue:908
Sequence:
MVCEGKRLASCPCFFLLTAKFYWILTMMQRTHSQEYAHSIRVDGDIILGGLFPVHAKGER
GVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV
QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTA
PELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISR
EIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQS
GHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFA
EFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMH
KERCPGYIGLCPRMVTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQINN
KSTEYKIIGHWTNQLHLKVEDMQWANREHTHPASVCSLPCKPGERKKTVKGVPCCWHCER
CEGYNYQVDELSCELCPLDQRPNINRTGCQRIPIIKLEWHSPWAVVPVFIAILGIIATTF
VIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRIFLGLGMC
FSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPH
TIIDYGEQRTLDPENARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEA
KPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYI
IIFHPEQNVQKRKRSFKAVVTAATMQSKLIQKGNDRPNGEVKSELCESLETNTSSTKTTY
ISYSNHSI
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  Blast E-value cutoff:
BDBM196914
n/a
NameBDBM196914
Synonyms:US9212196, Derivative 10
TypeSmall organic molecule
Emp. Form.C15H22NO8P
Mol. Mass.375.3108
SMILESCc1cc(cc(C)c1OCC(O)=O)C(O)P(O)(=O)CC[C@@H](N)C(O)=O |r|
Structure
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